{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:36:04Z","timestamp":1777509364909,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The left piriform cortex and amygdala (PC&amp;A) is an early target for deterioration due to aging and Alzheimer's disease (AD) in several neuropathological and magnetic resonance (MR) volumetric studies. We observed slight hyperintensity of the left PC&amp;A in older adults and probable AD (pAD) patients on T2-weighted fluid-attenuated inversion recovery (T2W-FLAIR) images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To quantitatively assess the validity of the left PC&amp;A hyperintensity in older adults and pAD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>T2W-FLAIR images from three groups were retrospectively evaluated: (i) younger control (YC; n\u2009=\u200977): individuals aged 37.9\u2009\u00b1\u20098.4 years; (ii) older control (OC; n\u2009=\u200998): individuals aged 76.9\u2009\u00b1\u20095.3 years without cognitive impairment; and (iii) pAD (n\u2009=\u200935): individuals aged 80.5\u2009\u00b1\u20096.9 years with pAD. Signal intensity (SI) ratios of the left to right PC&amp;A (L-PC&amp;A\/R-PC&amp;A) were calculated for all groups. In the OC and pAD groups, SI ratios of the left PC&amp;A to pons (L-PC&amp;A\/P) and the right PC&amp;A to pons (R-PC&amp;A\/P) were calculated. The regions of interest were defined as large as possible on transaxial images in which the PC&amp;As were most broadly depicted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean L-PC&amp;A\/R-PC&amp;A in the YC, OC, and pAD groups showed an increasing trend in that sequence\n                      <jats:italic>(P\u2009<\/jats:italic>\n                      &lt;\u20090.001). The mean L-PC&amp;A\/P was higher in the pAD group than in the OC group (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &lt;\u20090.001). However, the mean R-PC&amp;A\/P was not significantly different between the OC and pAD groups (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.245).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SI of the left PC&amp;A on T2W-FLAIR images significantly increased with age and in individuals with pAD, likely reflecting the deterioration of the left PC&amp;A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251328261","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:00:09Z","timestamp":1742788809000},"page":"816-822","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Slight hyperintensity of the left piriform cortex and amygdala on T2-weighted FLAIR images in older adults and patients with probable Alzheimer's disease"],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2461-7764","authenticated-orcid":false,"given":"Hiroshi","family":"Ishizaka","sequence":"first","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nagase","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maebashi Red Cross Hospital, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Tsushima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, Graduate School of Medicine, Gunma University, Gunma, 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