{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:14:32Z","timestamp":1789398872768,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS083503"],"award-info":[{"award-number":["R01 NS083503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62271061"],"award-info":[{"award-number":["62271061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["83161120402"],"award-info":[{"award-number":["83161120402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between serum inflammatory biomarkers, carotid atherosclerotic plaque characteristics, and the recurrence of ischemic events remains a subject of ongoing debate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate whether the combination of carotid atherosclerotic plaque burden and serum inflammatory biomarkers could help predict ipsilateral ischemic stroke recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Patients with cerebral infarction were prospectively recruited and received three-dimensional vessel wall imaging (VWI). Baseline serum level of high-sensitivity C-reactive protein (hs-CRP) and the neutrophil-to-lymphocyte ratio (NLR) was recorded. Plaque burden was independently measured by two trained readers. Stroke recurrence was assessed at 1 year after discharge. Factors associated with stroke recurrence were analyzed. Receiver operating characteristic curves were used to calculate areas under the curve (AUCs) of inflammatory biomarkers and plaque burden for predicting stroke recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 56 patients were included, with recurrence in nine patients. hs-CRP (odds ratio [OR]\u2009=\u20091.60, 95% confidence interval [CI]\u2009=\u20091.17\u20132.19;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017) and carotid normalized wall index (NWI) (OR\u2009=\u20091.08, 95% CI\u2009=\u20091.01\u20131.16;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.023) were found associated with stroke recurrence. Multivariate logistic regression showed that hs-CRP (OR\u2009=\u20091.67, 95% CI\u2009=\u20091.17\u20132.38;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) and NWI (OR\u2009=\u20091.10, 95% CI\u2009=\u20091.01\u20131.20,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.023) remained associated with stroke recurrence. Hs-CRP (AUC = 0.806; P\u2009=\u20090.002) and NWI (AUC = 0.738;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;0.001) were predictors of stroke recurrence. The combination of hs-CRP with NWI (AUC = 0.811,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;0.001) demonstrated the best performance in terms of predicting stroke recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both hs-CRP and NWI were independently associated with stroke recurrence. The combination of hs-CRP and NWI may be a good predictor of 1-year stroke recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251340607","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T04:16:11Z","timestamp":1750133771000},"page":"1047-1056","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Incremental value of serum inflammatory biomarkers to carotid atherosclerotic plaque burden for prediction of ipsilateral ischemic stroke recurrence"],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2296-7366","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China"},{"name":"Department of Neurology, Beijing Daxing Hospital, Capital Medical University, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, PR China"},{"name":"Department of Radiology and Imaging Sciences Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0129-5846","authenticated-orcid":false,"given":"Thomas","family":"Hatsukami","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-0566","authenticated-orcid":false,"given":"Xihai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China"},{"name":"Beijing Neurosurgical Institute, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Sui","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Beijing, PR China"},{"name":"Tiantan Neuroimaging Center for Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China"},{"name":"China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, PR China"},{"name":"Research Unit of Artifcial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020913557"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.1.208"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019422"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4893"},{"key":"e_1_3_2_8_2","first-page":"975","article-title":"Diagnosis value comparation of high-resolution MR vessel wall imaging 3D CUBE T1 weighted sequence and SWI for cerebral venous sinus thrombosis","volume":"14","author":"Zhao B","year":"2019","unstructured":"Zhao B, Huang MM, Zhu MJ, et al. 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