{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:37:07Z","timestamp":1777509427530,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","award":["2021-4-033"],"award-info":[{"award-number":["2021-4-033"]}],"id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023-4-092"],"award-info":[{"award-number":["2023-4-092"]}],"id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intensity-modulated radiotherapy targeting areas of active bone marrow effectively reduces hematological toxicity; consequently, it is important to determine whether the bone marrow is active.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore diffusion-weighted imaging (DWI) signal as a potential tool for assessing bone marrow function in middle-aged and elderly patients with rectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective study investigated clinical and magnetic resonance imaging (MRI) data from middle-aged and elderly patients with rectal cancer. Pelvic bone marrow DWI signals (b\u2009=\u2009800\u2005s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ) were classified as high and iso-low signal groups. Factors influencing the DWI signal were analyzed individually in a multifactorial analysis. Subsequently, a comparison was made of the intravoxel incoherent motion (IVIM) parameters between the high and iso-low signal groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study involved 73 patients, with 32 in the high-signal and 41 in the iso-low-signal groups. The multifactorial analysis showed that anemia (odds ratio [OR]\u2009=\u20095.264;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.025) and proton density fat fraction (PDFF) (OR\u2009=\u20090.872;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001) were independent factors influencing the DWI signal. In addition, the high-signal group demonstrated significantly lower values of the standard apparent diffusion coefficient (ADC) (median = 0.466 \u00d710\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\u00b2\/s, interquartile range = 0.413\u20130.550 vs. 0.534 \u00d710\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\u00b2\/s, interquartile range = 0.495\u20130.594;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.01) and the mean diffusion coefficient (D) (0.423\u2009\u00b1\u20090.065 vs. 0.482\u2009\u00b1\u20090.090,\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\u00b2\/s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The evaluation of pelvic bone marrow function through DWI signals is feasible in middle-aged and elderly patients with rectal cancer. A high DWI signal in the pelvic bone marrow correlates with post-anemic cellular proliferation, indicating active hematopoiesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251360344","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:17:16Z","timestamp":1758046636000},"page":"1217-1224","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffusion-weighted imaging signal as a predictor of pelvic bone marrow activity in middle-aged and elderly patients with rectal cancer"],"prefix":"10.1177","volume":"66","author":[{"given":"Liang","family":"Hu","sequence":"first","affiliation":[{"name":"Jinhua Municipal Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Feng","family":"Pan","sequence":"additional","affiliation":[{"name":"Jinhua Municipal Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4904-487X","authenticated-orcid":false,"given":"Zheng","family":"Han","sequence":"additional","affiliation":[{"name":"Jinhua Municipal Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Mei","family":"Xia","sequence":"additional","affiliation":[{"name":"Jinhua Municipal Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0116-z"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020852"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.30097"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00120-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14184425"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40134-017-0218-8"},{"key":"e_1_3_2_8_2","first-page":"100801","article-title":"Clinical outcomes of pelvic bone marrow sparing radiotherapy for cervical cancer: a systematic review and meta-analysis of randomised controlled trials","volume":"47","author":"Miszczyk M","year":"2024","unstructured":"Miszczyk M, Wu T, Kuna K, et al. 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