{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:09:52Z","timestamp":1785276592881,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Meningiomas are the most common extra-axial tumors of the central nervous system, and accurate preoperative assessment of their histological grade is essential for effective treatment planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the relationship between the apparent diffusion coefficient (ADC) sequence, histopathological grade, and Ki-67 proliferation index for radiologically identifying meningiomas with poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      The study included 90 patients with histopathologically confirmed meningioma between March 2019 and February 2021. The Ki-67 proliferation index was assessed using an image analysis program. Retrospectively, ADC maps and diffusion-weighted imaging (DWI) were reviewed. An oval-shaped region of interest was placed over the lesion's solid component and the normal-appearing white matter in the opposite hemisphere. Each patient's ADC ratio (ADC meningioma\/ADC normal-appearing white matter) was calculated. The relationship between ADC and Ki-67 proliferation index was investigated, and ADC values of benign and atypical meningiomas were compared. Independent sample\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test, Mann\u2013Whitney U test, and receiver operating characteristic were used for statistical assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean ADC value was 844.11\u2009\u00b1\u2009123.55 mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s for low-grade and 743.75\u2009\u00b1\u200992.64 mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s for high-grade meningiomas. The mean ADC ratio was 1.11\u2009\u00b1\u20090.19 for low-grade and 1.00\u2009\u00b1\u20090.15 for high-grade meningiomas. Both ADC values and ADC ratio significantly distinguished histopathologic grades (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.030, respectively). No significant correlation was found between ADC values or ADC ratio and the Ki-67 proliferation index (r\u2009=\u2009\u22120.123,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.248; r\u2009=\u20090.033,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.755).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A statistically significant difference was found between ADC values and ADC ratio of low- and high-grade meningiomas. There was no correlation between either ADC values or ADC ratio and Ki-67 proliferation index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251365512","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T05:32:14Z","timestamp":1755495134000},"page":"1263-1270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["ADC values compared to tumor grade and Ki-67 proliferation index detected by a digital image analysis program in meningiomas"],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-7319","authenticated-orcid":false,"given":"Hanife","family":"Ersay","sequence":"first","affiliation":[{"name":"Ankara Bilkent City Hospital, Ankara, T\u00fcrkiye"},{"name":"Department of Radiology, Faculty of Medicine, Laval University, Quebec City, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Gul","family":"Hatipoglu","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servet","family":"Guresci","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.01.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2010.09.002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300101025"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.3.8109520"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0094-z"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-024-03404-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12030630"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0284185120922142"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2020.11.1126"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11637"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140842"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.10.049"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.06.031"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0657-y"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.10.010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24397"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4531"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116975"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3171\/2023.6.JNS222483"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox112"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112605"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-023-00937-3"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0571-y"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851251365512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851251365512","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851251365512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:34:47Z","timestamp":1777390487000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851251365512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,17]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/02841851251365512"],"URL":"https:\/\/doi.org\/10.1177\/02841851251365512","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,17]]}}}