{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:37:19Z","timestamp":1777509439058,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-001A"],"award-info":[{"award-number":["TJYXZDXK-001A"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-resolution magnetic resonance imaging (MRI) is a feasible method for identifying and measuring luminal thrombosis in the occluded middle cerebral artery (MCA) of stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the relationship between thrombus length in the middle cerebral artery (MCA) and clinical prognosis in stroke patients using high-resolution MRI (T1-weighted [T1W]-CUBE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In this retrospective study, patients with MCA thrombi were identified via high-resolution MRI. Thrombus length was measured using T1W-CUBE sequences, and clinical prognosis was assessed using modified Rankin scale (mRS) scores at a 3-month follow-up. Patients were categorized into good or poor prognosis groups based on mRS scores. Statistical analyses compared thrombus length and diameter between groups. Restricted cubic spline (RCS) analyses were performed to examine the relationship between thrombus length, diameter, and mRS scores. Multiple logistic regression was used to explore the association between thrombus length and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean thrombus length was significantly longer in the poor prognosis group compared to the good prognosis group (25.69\u2009\u00b1\u20098.78\u2005mm vs. 15.11\u2009\u00b1\u20096.91\u2005mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001). Thrombus diameter did not significantly differ between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.961). RCS showed a monotonically increasing relationship between thrombus length and log OR of mRS. Multiple logistic regression indicated that each additional millimeter of thrombus length increased the risk of poor prognosis by 1.22 times (odds ratio\u2009=\u20091.22, 95% confidence interval = 1.11\u20131.40;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCA thrombus length is a significant predictor of prognosis in stroke patients, with longer thrombi associated with worse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251367354","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:24:03Z","timestamp":1755588243000},"page":"1278-1285","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Thrombus length predicts outcome of middle cerebral artery occlusion: a high-resolution MRI study"],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-4349","authenticated-orcid":false,"given":"Chao","family":"Zhang","sequence":"first","affiliation":[{"name":"Tianjin Medical University General Hospital"},{"name":"Department of Radiology, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital, Jinan, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital, Jinan, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital, Jinan, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro","family":"Pylypenko","sequence":"additional","affiliation":[{"name":"MR Research China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-2401","authenticated-orcid":false,"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012781"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076727"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.580662"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-020-01754-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013454"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12373"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2018.01921"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1298-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.11679"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3533"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-019-00841-w"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06437-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000279"},{"key":"e_1_3_2_15_2","first-page":"78","article-title":"Effect on successful recanalization of thrombus length in susceptibility- weighted imaging in mechanical thrombectomy with stentretrieval","volume":"18","author":"Lee DH","year":"2021","unstructured":"Lee DH, Sung JH, Yi HJ, et al. 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