{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:37:20Z","timestamp":1777509440536,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005940","name":"Dansk Kr\u00e6ftforsknings Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005940","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment response assessment can be challenging in bone-metastasizing breast cancer. Whole-body magnetic resonance imaging (WB-MRI) is superior to contrast-enhanced computed tomography (CE-CT) for detecting progressive disease (PD) in bone-only metastatic breast cancer; however, the ability to detect PD in mixed visceral- and bone-metastasizing breast cancer remains to be assessed in prospective studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To prospectively compare WB-MRI and CE-CT for detecting PD in mixed visceral- and bone-metastasizing breast cancer and determine if WB-MRI could detect PD earlier than CE-CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 43 women with mixed visceral- and bone-metastasizing breast cancer were prospectively followed with WB-MRI and CE-CT from the initiation of new chemotherapy. Kaplan\u2013Meier analysis of time to progression was performed for both WB-MRI and CE-CT, and the time difference between the two was compared using a one-sample\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test. The ability to detect PD earliest was compared using McNemar\u2019s test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 43 patients enrolled, 21 completed the study. Treatment was changed due to PD in 18 patients and due to side effects in three patients. Median time until change of treatment was 8 months (range=4\u201321 months). WB-MRI correctly detected PD in 16\/18 patients compared to 13\/18 for CE-CT. A total of 73 pairs of examinations were analyzed, of which WB-MRI detected PD earliest in 7\/18 patients compared to 1\/18 for CE-CT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.035).. There were no statistically significant differences in time to progression between WB-MRI and CE-CT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.41).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WB-MRI can detect PD in women with mixed visceral- and bone-metastasizing breast cancer earlier than CE-CT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251368896","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:55:12Z","timestamp":1756209312000},"page":"1286-1294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of whole-body MRI and contrast-enhanced CT for treatment response assessment of mixed visceral- and bone-metastasizing breast cancer"],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-6389","authenticated-orcid":false,"given":"Thomas Winther","family":"Buus","sequence":"first","affiliation":[{"name":"Aarhus University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-7053","authenticated-orcid":false,"given":"Jill Rachel","family":"Mains","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders Bonde","family":"Jensen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik Morre","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0931"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.194"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.2388"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.09.019"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.03.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.282075068"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.772530"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2018.06.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-022-02784-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-024-04723-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019181949"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.05.033"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.03.001"},{"key":"e_1_3_2_16_2","first-page":"275","article-title":"Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display","volume":"22","author":"Takahara T","year":"2004","unstructured":"Takahara T, Imai Y, Yamashita T, et al. 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