{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:37:54Z","timestamp":1777509474790,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatic cancer has poor outcomes, with vascular invasion being a critical factor in determining resectability and prognosis. Accurate assessment of vascular invasion remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the predictors of vascular invasion and recurrence-free survival (RFS) in patients with pancreatic cancer undergoing surgery after chemotherapy using computed tomography (CT) and histopathological data, and to evaluate the diagnostic performance of CT-based vascular scoring system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 98 patients with pancreatic cancer showing vascular encasement on CT who underwent chemotherapy before surgery. Two reviewers evaluated baseline and preoperative CT to assess resectability. Clinicohistopathological factors were assessed. RFS was analyzed using the Kaplan\u2013Meier method. The predictors were identified using Cox proportional hazards and logistic regression models. A 3-point scoring system quantified vascular involvement at baseline and preoperative CT, with total scores combining both time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 98 patients, 32 (32.7%) had pathologically confirmed vascular invasion. Change in tumor size (odds ratio [OR]=3.1;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.022), T stage (OR=15.4;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.038), and perineural invasion (OR=13.2;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.028) predicted vascular invasion. Total vascular scores strongly correlated with vascular invasion (areas under the curve=0.924 and 0.803). Median RFS was 21 months, influenced by lymph node involvement at baseline and preoperative CT (hazard ratio [HR]=2.3;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.009 and HR=2.6;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.013, respectively), tumor differentiation (HR=3.3;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.047), and elevated CA 19\u20139 (HR=2.8;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Changes in tumor size on CT, T stage, and perineural invasion predict vascular invasion. In addition, a CT-based scoring systems can accurately predict vascular invasion after chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251399897","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T16:22:46Z","timestamp":1764606166000},"page":"166-177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Key preoperative findings for predicting vascular invasion and recurrence after conversion surgery after chemotherapy in pancreatic cancer"],"prefix":"10.1177","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-8247","authenticated-orcid":false,"given":"Sungjun","family":"Hwang","sequence":"first","affiliation":[{"name":"Inje University Ilsan Paik Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-7758","authenticated-orcid":false,"given":"Jung Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital"},{"name":"Department of Radiology, Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University Medical Research Center, Jongno-gu, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghoan","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rae Rim","family":"Ryu","sequence":"additional","affiliation":[{"name":"Chung-Ang University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Tempero MA Malafa MP Basturk O et al. Pancreatic Adenocarcinoma Version 2.2025. NCCN Clinical Practice Guidelines in Oncology. National Comprehensive Cancer Network; 2025."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/AS9.0000000000000219"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13027"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.08.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000867"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.168.6.9168704"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27636"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9969"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.02.001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08304-y"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152790"},{"key":"e_1_3_2_14_2","first-page":"105","article-title":"The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal","volume":"3","author":"Ballehaninna UK","year":"2012","unstructured":"Ballehaninna UK, Chamberlain RS. The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal. 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Predictors of survival rate in patients with pancreatic cancer: a multi-center analytical study in Iran. 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