{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:01Z","timestamp":1777509481616,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although prior studies on peripheral arteriovenous malformations (AVMs) have addressed diagnosis and treatment, the prevalence and risk factors for cardiomegaly remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the prevalence of cardiomegaly in peripheral AVMs, identify associated factors, and evaluate changes in cardiac size and function following endovascular treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A retrospective review was conducted on 437 patients treated for peripheral AVMs between 2000 and 2022 at a single vascular anomalies center. AVM types were classified according to the Cho-Do angiographic classification. Cardiomegaly was defined as a cardiothoracic ratio (CTR) &gt;0.5 on chest radiographs. Factors associated with cardiomegaly and post-treatment changes in CTR and cardiac function were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cardiomegaly was observed in 108\/437 (24.7%) patients. Multivariate analysis identified type I\/II (vs. III) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002), lesion diameter &gt;10\u2005cm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.013), and bone involvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.021) as significant risk factors. Abdominopelvic (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001) and thoracic-neck AVMs (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.018) had higher cardiomegaly prevalence than extremity AVMs. Among the 108 patients with cardiomegaly, 84 underwent follow-up chest radiographs. The median CTR reduction rate was 8.9% (interquartile range [IQR] 4.1\u201315.8), with a significant decrease (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001). Higher angiographic devascularization was associated with greater CTR reductions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.013). Echocardiography was selectively performed in patients with suspected cardiac involvement. Among 27 patients with both pre- and post-treatment echocardiography, 44% showed functional improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AVM type, extent, location, and bone involvement were significant factors influencing cardiomegaly risk. Endovascular treatment was effective in reducing cardiac enlargement and functional improvement was observed in a subset of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851251405785","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:51:27Z","timestamp":1766076687000},"page":"208-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors influencing cardiomegaly and cardiac size changes after endovascular treatment in peripheral arteriovenous malformations"],"prefix":"10.1177","volume":"67","author":[{"given":"Jun Gon","family":"Kim","sequence":"first","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-9015","authenticated-orcid":false,"given":"Myung Sub","family":"Kim","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-8229","authenticated-orcid":false,"given":"Sang Yub","family":"Lee","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Bo","family":"Park","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Soo","family":"Do","sequence":"additional","affiliation":[{"name":"Hallym University Sacred Heart Hospital, College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Seok","family":"Yang","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169037"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1592077"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2019.12.811"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/15266028231166546"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Park KB Do YS Kim DI et al. 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