{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:24:30Z","timestamp":1780410270568,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Young Scholars Fostering Fund fo the First Affiliated Hospital of Nanjing Medical University","award":["Grant Nos. PY2022036"],"award-info":[{"award-number":["Grant Nos. PY2022036"]}]},{"name":"Jiangsu Province Capability Improvement Project through Science, Technology and Education","award":["Grant Nos.JSDW202243 for Xiaoquan Xu"],"award-info":[{"award-number":["Grant Nos.JSDW202243 for Xiaoquan Xu"]}]},{"name":"Natural Scientific Foundation of China","award":["Grant Nos. 82302163"],"award-info":[{"award-number":["Grant Nos. 82302163"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>White matter hyperintensity (WMH) is a common finding in brain magnetic resonance imaging (MRI), but its relationship with coronary plaque characteristics remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the association between coronary computed tomography angiography (CCTA)-derived plaque characteristics and WMH in brain MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      CCTA and brain MRI of 392 consecutive patients were retrospectively collected. Degree of total WMH was evaluated based on Fazekas scale (0\u20136) and classified into mild (0\u20132) and moderate-to-severe (3\u20136) groups. Besides demographic and clinical data, morphological and quantitative parameters (e.g. aortic ulcer, Agatston Score, diameter stenosis, plaque volume, plaque length) were also evaluated based on CCTA. Chi-square (or Fisher's exact) test and Student's\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test (or Wilcoxon's signed-rank test) were used for comparing variables between two groups when appropriate. Multivariate logistic regression analyses were applied to identify the independent variables associated with moderate-to-severe WMH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with moderate-to-severe WMH showed older age, larger plaque burden, plaque length, volume of noncalcified and calcified plaque, higher total cholesterol, triglyceride, low-density lipoprotein, Agatston Score, and higher proportion of male, hypertension, diabetes, aortic ulcer, and obstructive coronary artery disease (CAD) (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009\u2009&lt;\u20090.05). Age (odds ratio [OR]=1.061, 95% confidence interval [CI]=1.013\u20131.111;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.012), plaque burden (OR=15.259, 95% CI=2.466\u201394.412;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003), obstructive CAD (OR=8.020, 95% CI=3.628\u201317.727;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001), and Agatston Score (OR=1.004, 95% CI=1.002\u20131.006;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001) were found to be independently associated with moderate-to-severe WMH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older age, larger plaque burden, higher Agatston score, and obstructive CAD were prone to moderate-to-severe WMH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851261421597","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:45:57Z","timestamp":1774845957000},"page":"477-486","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of coronary computed tomography angiography-derived plaque characteristics and brain white matter hyperintensity: an observational study"],"prefix":"10.1177","volume":"67","author":[{"given":"Jie","family":"Qin","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University"},{"name":"Northern Jiangsu People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical 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