{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:24:33Z","timestamp":1780410273837,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"\n Background<\/jats:title>\n Diffusion-weighted magnetic resonance imaging (DWI) of prostate cancer (PCa) is commonly quantified using monoexponential apparent diffusion coefficient (ADCm) values. However, repeatability of ADCm as qualitative biomarker for PCa is not well established.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To evaluate repeatability of prostate ADCm.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n A total of 112 patients with PCa who underwent two repeated prostate DWI scans (12 b-values, 0\u20132000\u2005s\/mm\n 2<\/jats:sup>\n ) on the same day before prostatectomy. ADCm values were analyzed across different b-value combinations and PCa lesion sizes. Bland\u2013Altman plots, Spearman rank correlation, within-subject standard deviation (wSD), and coefficient of variation (wCV) were calculated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Bland\u2013Altman plots demonstrated no observable trend differences across ADCm intensity ranges. The results indicate correlation of ADCm repeatability with PCa aggressiveness, expressed as Gleason Grade Group (GGG). Specifically, wCV decreased towards higher GGG compared with GGG=1, wCV was <0.07 with b-value pairs from 0, 700 to 0, 1300\u2005s\/mm\n 2<\/jats:sup>\n . Majority of evaluated lesions that had high wSD up to 0.2\u2009\u00d7\u200910\n \u22123<\/jats:sup>\n \u2005mm\n 2<\/jats:sup>\n \/s were found in lower GGGs. Different b-value combinations demonstrated varying effects on ADCm performance. The lowest repeatability was observed with the lesion size <5\u2005mL while for the lesion size \u22655\u2005mL wSD was <0.1\u2009\u00d7\u200910\n \u22123<\/jats:sup>\n \u2005mm\n 2<\/jats:sup>\n \/s.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our study demonstrated repeatability of ADCm mean values as quantitative imaging biomarkers for PCa detection and characterization.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/02841851261441869","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:02:21Z","timestamp":1776690141000},"page":"502-507","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-term repeatability of monoexponential apparent diffusion coefficient in prostate cancer: dependence on b-value, tumor grade, lesion size, and lesion location"],"prefix":"10.1177","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6305-3570","authenticated-orcid":false,"given":"Ivan","family":"Jambor","sequence":"first","affiliation":[{"name":"University of Turku"},{"name":"Enterprise Service Group - Radiology, Mass General Brigham, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Merisaari","sequence":"additional","affiliation":[{"name":"University of Turku"},{"name":"Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2016.07.06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.04.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.07.004"},{"key":"e_1_3_2_5_2","article-title":"Apparent diffusion coefficient for prostate cancer imaging: impact of b values","volume":"202","author":"Peng Y","unstructured":"Peng Y, Jiang Y, Antic T, et al. Apparent diffusion coefficient for prostate cancer imaging: impact of b values. AJR Am J Roentgenol 2014 202: W247.","journal-title":"AJR Am J Roentgenol 2014"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06725-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Toivonen J Montoya Perez I Movahedi P et al. Radiomics and machine learning of multisequence multiparametric prostate MRI: towards improved non-invasive prostate cancer characterization. PLoS One 2019;88:1\u201332.","DOI":"10.1371\/journal.pone.0217702"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.11.014"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Merisaari H Taimen P Shiradkar R et al. Repeatability of radiomics and machine learning for DWI: short-term repeatability study of 112 patients with prostate cancer. Magn Reson Med 2020;83:2293\u20132309.","DOI":"10.1002\/mrm.28058"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Rogers HJ Singh S Barnes A et al. Test-retest repeatability of ADC in prostate using the multi b-value VERDICT acquisition. Eur J Radiol 2023;162:110782.","DOI":"10.1016\/j.ejrad.2023.110782"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.09.046"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26518"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0962280214537344"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Jambor I Merisaari H Taimen P et al. Evaluation of different mathematical models for diffusion-weighted imaging of normal prostate and prostate cancer using high b-values: a repeatability study. Magn Reson Med 2015;73:1988\u20131998.","DOI":"10.1002\/mrm.25323"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851261441869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851261441869","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851261441869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:47:37Z","timestamp":1780408057000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851261441869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/02841851261441869"],"URL":"https:\/\/doi.org\/10.1177\/02841851261441869","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}