{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:13:35Z","timestamp":1783469615517,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["20OC0065520"],"award-info":[{"award-number":["20OC0065520"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007954","name":"Fondation Idella","doi-asserted-by":"crossref","award":["grant no: 3.3.3.\/I\/2023"],"award-info":[{"award-number":["grant no: 3.3.3.\/I\/2023"]}],"id":[{"id":"10.13039\/501100007954","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oxaliplatin is used in colorectal cancer treatment (CRC) but frequently causes chemotherapy-induced peripheral neuropathy (CIPN), a cumulative and potentially chronic adverse event. Reliable non-invasive methods for the early detection and monitoring of CIPN are lacking. Shear wave elastography (SWE) is an ultrasound-based technique that quantifies peripheral nerve stiffness and may enable CIPN assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the feasibility of SWE for detecting CIPN from oxaliplatin treatment in CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In this prospective, single-blinded study, patients with stage III\u2013IV CRC receiving oxaliplatin-based (n\u2009=\u200918) or non-oxaliplatin chemotherapy (n\u2009=\u200912) were assessed at baseline, 3 months, and 6 months. Tibial nerve SWE, cross-sectional area, and diameter were measured using a standardized ultrasound protocol. CIPN symptoms were recorded through structured interviews, yielding composite scores (0\u201310), with possible CIPN defined as \u22652 points. Healthy controls (n\u2009=\u20099) underwent a single SWE evaluation. Linear mixed-effects models and non-parametric tests were used for longitudinal and group comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nerve diameter increased over time in both groups (+1.50\u2005mm, 95% confidence interval = 0.78\u20132.21;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.001) without between-group differences. SWE showed a trend toward higher tibial nerve stiffness at 6 months in oxaliplatin-treated patients (29.75 vs. 20.81\u2005kPa). Possible CIPN occurred in 70% of oxaliplatin-treated patients versus none in the non-oxaliplatin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.01). SWE correlated with CIPN scores (\u03c1\u2009=\u20090.55;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SWE is a feasible, non-invasive method, and tibial nerve stiffness was modestly associated with CIPN symptom severity at 6 months. These findings are hypothesis-generating, and larger studies with validated neuropathy instruments are warranted to confirm clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851261447858","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:55:57Z","timestamp":1780664157000},"page":"613-622","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasonographic assessment of chemotherapy-induced peripheral neuropathy after oxaliplatin treatment: an exploratory study"],"prefix":"10.1177","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-4139","authenticated-orcid":false,"given":"Nina Lykkegaard","family":"Gehr","sequence":"first","affiliation":[{"name":"University Hospital of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-7968","authenticated-orcid":false,"given":"Malene Roland","family":"Vils Pedersen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, Faculty of Health Serviced, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Radiology, University Hospital of Southern Denmark, Vejle, Denmark"},{"name":"Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark"},{"name":"Discipline of Medical Imaging and Radiation Therapy, School of Medicine, University College Cork, Cork, Ireland"},{"name":"Education in Radiography, VIA University College, Herning, Denmark"},{"name":"Education of Radiography, VIA University College, Herning, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7476-671X","authenticated-orcid":false,"given":"Torben Fr\u00f8strup","family":"Hansen","sequence":"additional","affiliation":[{"name":"University Hospital of Southern Denmark"},{"name":"Department of Regional Health Research, Faculty of Health Serviced, University of Southern Denmark, Odense, Denmark"},{"name":"Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Henrik","family":"Jensen","sequence":"additional","affiliation":[{"name":"University Hospital of Southern Denmark"},{"name":"Department of Regional Health Research, Faculty of Health Serviced, University of Southern Denmark, Odense, Denmark"},{"name":"Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-7784","authenticated-orcid":false,"given":"Signe","family":"Timm","sequence":"additional","affiliation":[{"name":"University Hospital of Southern Denmark"},{"name":"Department of Regional Health Research, Faculty of Health Serviced, University of Southern Denmark, Odense, Denmark"},{"name":"Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Ventzel","sequence":"additional","affiliation":[{"name":"University Hospital of Southern Denmark"},{"name":"Department of Regional Health Research, Faculty of Health Serviced, University of Southern Denmark, Odense, Denmark"},{"name":"Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Rafael","family":"Rafaelsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, Faculty of Health Serviced, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Radiology, University Hospital of Southern Denmark, Vejle, Denmark"},{"name":"Danish Colorectal Cancer Center South, University Hospital of Southern Denmark, Vejle, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Ventzel L Jensen AB Jensen AR et al. 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