{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:14:44Z","timestamp":1783469684788,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Young-onset breast cancer (\u226440 years) may demonstrate distinct magnetic resonance imaging (MRI) features compared with older patients, and recognition of age-related phenotypes may improve radiologic\u2013pathologic correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate dynamic breast MRI features of young-onset breast cancer, assess their correlation with histopathological characteristics, and compare these findings with those observed in an older patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This retrospective study included 160 women with breast cancer (80 aged \u226440 years; 80 aged \u226550 years). Breast density, background parenchymal enhancement (BPE), edema, skin thickness, lesion margins, T2 signal intensity, rim enhancement, internal enhancement pattern, kinetic curve type, ADC values were assessed according to ACR BI-RADS MRI lexicon. Histopathological features were extracted from pathology reports. Statistical analyses were performed using SPSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Younger women more frequently demonstrated dense fibroglandular tissue, higher BPE, rim enhancement, T2 iso- to hyperintense lesions, and persistent enhancement kinetics (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.05). In contrast, older patients more commonly showed irregular morphology, diffuse edema, T2 hypointensity, and increased skin thickness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;0.05). In the young-onset cohort, rim enhancement was associated with HER2-positive tumors (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006), and heterogeneous enhancement was associated with diffuse edema (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002). An ADC threshold of &lt;830\u2009\u00d7\u200910\n                      <jats:sup>\u22126<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s predicted invasive carcinoma of no special type with 49.2% sensitivity and 80.0% specificity. In patients aged \u226550 years, rim enhancement was associated with triple-negative subtype (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Breast cancer in women aged \u226440 years exhibits distinct MRI features compared with older patients. Findings such as circumscribed margins, T2 iso\/hyperintensity, and persistent enhancement may still reflect aggressive tumor biology in young women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851261457446","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:02:30Z","timestamp":1780923750000},"page":"623-635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic breast magnetic resonance imaging features and pathological correlation of patients diagnosed with breast cancer under the age of 40"],"prefix":"10.1177","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7692-4085","authenticated-orcid":false,"given":"Velican","family":"Gundogdu","sequence":"first","affiliation":[{"name":"Department of Radiology, Esenyurt State Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3927-321X","authenticated-orcid":false,"given":"Emine","family":"Meltem","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4728-1802","authenticated-orcid":false,"given":"Melis Baykara","family":"Ulusan","sequence":"additional","affiliation":[{"name":"Clinical Radiology-Breast Radiology, Nottingham Breast Institute, Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0794-0052","authenticated-orcid":false,"given":"Huseyin","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-0006","authenticated-orcid":false,"given":"Abdullah Soydan","family":"Mahmutoglu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_2_3_2","volume-title":"Breast Cancer. 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