{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:11:27Z","timestamp":1790097087361,"version":"4.0.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"\n Background<\/jats:title>\n The relationship between acute myocardial injury and prognosis in acute myocarditis (AM) is unclear.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To evaluate myocardial injury characteristics by cardiovascular magnetic resonance (CMR) tissue parameters and their impact on adverse outcomes of AM patients.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n This retrospective study enrolled 41 patients with fulminant myocarditis (FM, including 17 FM patients without mechanical circulatory support [MCS] and 24 FM patients with MCS) and 35 patients with non-fulminant myocarditis (non-FM). Cine, mapping (native T1, T2, and post-T1), and late gadolinium enhancement (LGE) of the left ventricle were performed during CMR. Adverse clinical outcomes consisted of a primary endpoint, major adverse cardiovascular events (MACEs), and a secondary endpoint, a decline in functional status (defined as New York Heart Association [NYHA] functional classes II\u2013IV).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with patients with non-FM, those in FM with MCS exhibited increased native T1 (\n P<\/jats:italic>\n \u2009=\u20090.001), extracellular volume (ECV) (\n P<\/jats:italic>\n \u2009=\u20090.018), and LGE (\n P<\/jats:italic>\n \u2009=\u20090.005) values. After adjusting for the clinical variables (CRP\u2009>\u200967.9\u2005mg\/dL), LGE\u2009>\u20098.4% remained independently associated with adverse clinical outcomes and improved the predicting ability of the model (C-statistic improved from 0.74 to 0.82).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The burden of necrosis and fibrosis was greatest in FM with MCS, while edema was similar across groups. Higher LGE% adds incremental prognostic value. A new classification using CRP and LGE improved prediction of adverse outcomes. Thus, CMR evaluation of myocardial injury extent offers variable information to improve risk stratification in FM.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/02841851261477088","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:09:05Z","timestamp":1787065745000},"page":"811-821","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Late gadolinium-enhanced cardiac MRI and C-reactive protein for predicting clinical prognosis of acute myocarditis in adults"],"prefix":"10.1177","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4987-2822","authenticated-orcid":false,"given":"Xiayun","family":"Shi","sequence":"first","affiliation":[{"name":"Southeast University Affiliated Nantong First People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongman","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianle","family":"Wang","sequence":"additional","affiliation":[{"name":"Southeast University Affiliated Nantong First People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital with Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.01.039"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-22-0696"},{"key":"e_1_3_2_4_2","first-page":"87","article-title":"Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes","volume":"5","author":"Hang W","year":"2020","unstructured":"Hang W, Chen C, Seubert JM, et al. Fulminant myocarditis: a comprehensive review from etiology to treatments and outcomes. Signal Transduct Target Ther 2020; 5: 87.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9020034"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-02097-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.11.017"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.03.011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.072"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Shi X Zhang Z Yin F et al. Cardiac magnetic resonance imaging (MRI) for detecting acute myocardial injury of fulminant myocarditis survivors after extracorporeal membrane oxygenation (ECMO) treatment in adults. Clin Radiol 2024;79:589-598.","DOI":"10.1016\/j.crad.2024.05.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy713"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.1061"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.026386"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000745"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1104715"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021203998"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015351"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.10.079"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0709-z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.839763"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851261477088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851261477088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851261477088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:52:01Z","timestamp":1790095921000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851261477088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/02841851261477088"],"URL":"https:\/\/doi.org\/10.1177\/02841851261477088","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}