{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:01:15Z","timestamp":1790089275696,"version":"4.0.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The utility of saline flush in portal venous phase (PVP) contrast-enhanced computed tomography (CECT) for the liver remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the effect of saline flush after contrast injection on liver and portal venous system enhancement in PVP CECT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The saline flush group prospectively included 97 consecutive patients (52 women; median age = 68 years) who underwent PVP CECT with saline flush. The control group retrospectively comprised 105 patients (63 women; median age = 65 years) who underwent PVP CECT without saline flush. Scanning protocols, including contrast injection protocol and scan timing (65\u2005s), were standardized. In the saline flush group, 20\u2005mL of saline, determined through a phantom study, was injected after contrast injection. Two radiologists measured increased CT attenuations (\u0394HUs) of the liver, portal vein (PV), superior mesenteric vein (SMV), and splenic vein (SV), and compared them between the two groups. The proportions of cases with liver \u0394HU above and below 50 HU were also compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u0394HUs were higher for the liver (69.4 HU vs. 64.4 HU;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.004), PV (184.6 HU vs. 171.9 HU;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001), SMV (179.0 HU vs. 171.0 HU;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002), and SV (185.1 HU vs. 163.6 HU;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) in the saline flush group than in the control group. The proportion of cases with liver \u0394HU below 50 HU was not different between the two groups (5.2% in the saline flush group vs. 7.6% in the control group;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.57).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Saline flush may increase liver and portal venous system enhancement on PVP CECT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851261483224","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:27:16Z","timestamp":1788276436000},"page":"849-858","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved liver and portal venous system enhancement with saline flush after contrast injection in portal venous phase computed tomography"],"prefix":"10.1177","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-117X","authenticated-orcid":false,"given":"Tetsuro","family":"Kaga","sequence":"first","affiliation":[{"name":"Gifu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-4790","authenticated-orcid":false,"given":"Yoshifumi","family":"Noda","sequence":"additional","affiliation":[{"name":"Gifu University"},{"name":"Gifu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0551-3708","authenticated-orcid":false,"given":"Mizuki","family":"Hirata","sequence":"additional","affiliation":[{"name":"Gifu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Kawai","sequence":"additional","affiliation":[{"name":"Gifu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Gifu University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-1895","authenticated-orcid":false,"given":"Hiroki","family":"Kato","sequence":"additional","affiliation":[{"name":"Gifu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Gifu University"},{"name":"Gifu University"},{"name":"Innovation Research Center for Quantum Medicine, Graduate School of Medicine, Gifu University, Gifu, Japan"},{"name":"Gifu University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.3.r00se26718"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.197.1.7568859"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.1591"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.4.1800929"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.4.1741049"},{"key":"e_1_3_2_7_2","first-page":"484","article-title":"[Multislice CT of the thorax: effects of contrast material pushed with saline solution using a dual power injector on contrast material dose and perivenous artifacts]","volume":"61","author":"Sekiguchi R","year":"2001","unstructured":"Sekiguchi R, Nawano S, Satake M, et al. [Multislice CT of the thorax: effects of contrast material pushed with saline solution using a dual power injector on contrast material dose and perivenous artifacts]. 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