{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:44:39Z","timestamp":1792586679136,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate staging of cervical cancer is essential for treatment planning, with Magnetic Resonance Imaging (MRI) being the modality of choice. Cervical cancer is suspected to have variations in its presentation and etiology depending on the age of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the association between patient age and specific findings on contrast-enhanced MRI in women with newly diagnosed cervical cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This study included 146 consecutive patients with pathologically confirmed cervical cancer who underwent 3.0T contrast-enhanced MRI for initial staging. MRI scans were evaluated for tumor size, parametrium, uterine, bladder, and intestinal invasion, among other features. Ordinal, binary, and multinomial logistic regression models were used to assess age as a predictor for MRI stage and specific invasive findings. Receiver Operating Characteristic (ROC) curve analysis was performed for significant findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean patient age was 49.1\u2009\u00b1\u200912.2 years. Age was a significant predictor of a higher MRI stage (OR: 1.029, p\u2009=\u20090.025). Increasing age emerged as a significant predictor for uterine invasion (OR: 1.050, 95% CI: 1.022\u20131.085, p\u2009=\u20090.002), an association that remained significant even after controlling for disease stage. Age predicted higher odds of bladder mucosal (OR: 1.052, p\u2009=\u20090.011) and non-mucosal intestinal invasion (OR: 1.038, p\u2009=\u20090.041). ROC identified an age cutoff of 45.5 for uterine invasion (AUC: 65.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radiologists should maintain a heightened index of suspicion for more extensive local invasion when interpreting cervical cancer staging MRIs in older women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851261486043","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:44:25Z","timestamp":1789609465000},"page":"932-942","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age as a pre-operative predictor of uterine, bladder, and intestinal invasion in cervical cancer"],"prefix":"10.1177","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-7759","authenticated-orcid":false,"given":"Fahimeh","family":"Zeinalkhani","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences, Imam Khomeini Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Kamali Hakim","sequence":"additional","affiliation":[{"name":"Iran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-9535","authenticated-orcid":false,"given":"Amirmohammad","family":"Azizzadeh","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnia","family":"Jochin","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Mahdavi Sabet","sequence":"additional","affiliation":[{"name":"Islamic Azad University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadise","family":"Zeinalkhani","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.25259\/CMAS_03_02_2021"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvr.2022.200238"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12749"},{"key":"e_1_3_2_5_2","first-page":"10536","article-title":"CT, MRI, and PET imaging features in cervical cancer staging and lymph node metastasis","volume":"13","author":"Zhu Y","year":"2021","unstructured":"Zhu Y, Shen B, Pei X, et al. CT, MRI, and PET imaging features in cervical cancer staging and lymph node metastasis. Am J Transl Res 2021; 13: 10536\u201310544.","journal-title":"Am J Transl Res"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-025-05159-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2016.11.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-025-05076-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16040775"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205105"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-021-01488-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6318"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.01.017"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-021-05968-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-025-12039-5"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.10.012"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgc.2024.100008"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14953"},{"key":"e_1_3_2_19_2","article-title":"Cervical cancer invading the uterine corpus and sigmoid colon: a case report","volume":"36","author":"Huang S","year":"2022","unstructured":"Huang S, He F. Cervical cancer invading the uterine corpus and sigmoid colon: a case report. Case Rep Womens Health 2022; 36: e00455.","journal-title":"Case Rep Womens Health"},{"key":"e_1_3_2_20_2","first-page":"237","article-title":"Risk factors for parametrial invasion in early-stage cervical cancer: toward less radical surgery","volume":"22","author":"\u00c7eki\u00e7 SG","year":"2025","unstructured":"\u00c7eki\u00e7 SG, Bulut M, Ald\u0131ka\u00e7t\u0131o\u011flu Talma\u00e7 M, et al. Risk factors for parametrial invasion in early-stage cervical cancer: toward less radical surgery. J Turk Soc Obstet Gynecol 2025; 22: 237\u2013245.","journal-title":"J Turk Soc Obstet Gynecol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2022.03.026"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2268-3"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16111983"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07632-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-024-04339-z"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851261486043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851261486043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851261486043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:13:50Z","timestamp":1792584830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851261486043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/02841851261486043"],"URL":"https:\/\/doi.org\/10.1177\/02841851261486043","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}