{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:55:38Z","timestamp":1777467338430,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p>Magnetic resonance spectroscopy (MRS) may contribute to the characterization of intracranial tumors in vivo. Volume selective water suppressed proton spectroscopy offers the possibility to study a number of metabolites in the brain including choline (CHO), creatinine\/phosphocreatinine (CR\/PCR), N-acetylaspartate (NAA), and lactate. Using the stimulated echo technique we have studied 17 patients with intracranial tumors. In all cases the tumors were classified based on histologic evaluation. The tumor spectra differed considerably from those obtained in healthy brain tissue. The results indicate a relative decrease in the NAA and CR\/PCR content. In many cases a lactate peak could be seen especially in the tumors with malignant growth characteristics. Our preliminary results suggest that proton spectroscopy may contribute to the differentiation of brain tumors with respect to benign or malignant growth. However, further research is warranted before a definite conclusion can be drawn.<\/jats:p>","DOI":"10.1177\/028418519103200201","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T06:26:50Z","timestamp":1434004010000},"page":"95-99","source":"Crossref","is-referenced-by-count":25,"title":["In VIVO\n                    <sup>1<\/sup>\n                    H-Spectroscopy of Human Intracranial Tumors at 1.5 Tesla"],"prefix":"10.1177","volume":"32","author":[{"given":"O.","family":"Henriksen","sequence":"first","affiliation":[{"name":"From the Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, and the University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wieslander","sequence":"additional","affiliation":[{"name":"From the Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, and the University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gjerris","sequence":"additional","affiliation":[{"name":"From the Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, and the University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Jensen","sequence":"additional","affiliation":[{"name":"From the Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, and the University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.2.2748837"},{"key":"e_1_2_1_3_2","unstructured":"de Certaines J. D. Stubgaard M. Henriksen O.: Quality assessment in clinical 31P and 1H magnetic resonance spectroscopy. Book of abstracts p. 389. 7th Annual Congress of the European Society for MR in Medicine and Biology Strasbourg 1990."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910110105"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418519003100214"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.2.2296651"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.3.3187000"},{"key":"e_1_2_1_8_2","article-title":"Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis","volume":"12","author":"Larsson H.","year":"1990","unstructured":"Larsson H., Christiansen P., Jensen M., : Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magn. Reson. Med. 12 (1990),.","journal-title":"Magn. Reson. Med."},{"key":"e_1_2_1_9_2","first-page":"283","article-title":"Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR-spectroscopy","volume":"66","author":"Ordridge R. J.","year":"1986","unstructured":"Ordridge R. J., Connelly A., Lohman J. A. B.: Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR-spectroscopy. J. Magn. Reson. 66 (1986), 283.","journal-title":"J. Magn. 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