{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:33:35Z","timestamp":1777469615806,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3P2","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To test the possibility that (radio)activity of non-pertechnetate nature is excreted into the gastrointestinal tract at bone scintigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>\n                      The distribution of a bone-seeking radiopharmaceutical (\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-HDP) was studied in an experimental mouse system by dissecting different organs and assessing their activity with a gamma-counter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A comparison of the activity of the submandibular glands, which are assumed to accumulate only pertechnetate, and the gastrointestinal tract showed that a significant fraction of the activity excreted into the gastrointestinal tract did not consist of pertechnetate. Part of the excretion took place in the stomach. It was not connected to a specific bone-seeking agent or\n                      <jats:sup>99<\/jats:sup>\n                      Mo\/\n                      <jats:sup>99m<\/jats:sup>\n                      Tc generator. Nor did it increase with time between make-up and injection. The excretion of the non-pertechnetate acitvity was reduced by cimetidine and omeprazole. These gastric-secretion blocking drugs did not reduce excretion of pertechnetate or significantly affect the general distribution of the radiopharmaceutical.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a significant excretion of non-pertechnetate activity in the gastrointestinal tract. Part of this may be caused by excretion of the undegraded radiopharmaceutical by the stomach mucosa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851960373p271","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T06:26:50Z","timestamp":1434004010000},"page":"785-790","source":"Crossref","is-referenced-by-count":0,"title":["Activity in the Gastrointestinal Tract after Administration of Bone-Seeking Radiopharmaceuticals"],"prefix":"10.1177","volume":"37","author":[{"given":"M.","family":"Cronhjort","sequence":"first","affiliation":[{"name":"Departments of Diagnostic Radiology, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Departments of Hospital Physics, Karolinska Hospital, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-O.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Departments of Karolinska Pharmacy, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Garmelius","sequence":"additional","affiliation":[{"name":"Departments of Karolinska Pharmacy, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Jacobsson","sequence":"additional","affiliation":[{"name":"Departments of Diagnostic Radiology, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,5,1]]},"reference":[{"key":"bibr1-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252942"},{"key":"bibr2-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1148\/119.2.485"},{"key":"bibr3-02841851960373P271","first-page":"622","volume":"20","author":"Conway J. J.","year":"1979","journal-title":"J. Nucl. Med."},{"key":"bibr4-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199406000-00012"},{"key":"bibr5-02841851960373P271","first-page":"101","volume":"35","author":"Cronhjort M.","year":"1994","journal-title":"Radiol. Diagn."},{"key":"bibr6-02841851960373P271","unstructured":"European Pharmacopoiea, 2nd edn."},{"key":"bibr7-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1258\/002367792780745788"},{"key":"bibr8-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1407-9_15"},{"key":"bibr9-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(82)80009-3"},{"key":"bibr10-02841851960373P271","first-page":"817","volume":"18","author":"Kalin B.","year":"1991","journal-title":"Nucl. Med. Biol."},{"key":"bibr11-02841851960373P271","unstructured":"Kowalsky R. J., Perry J. R.: Radiopharmaceuticals in nuclear medicine practice, p. 351. Appleton & Lange Norwalk, Los Altos 1987."},{"key":"bibr12-02841851960373P271","first-page":"300","volume-title":"Differential diagnosis in nuclear medicine","author":"McAfee J. G.","year":"1984"},{"key":"bibr13-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-48-569-327"},{"key":"bibr14-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-4297-4_22"},{"key":"bibr15-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.13.4.8356264"},{"key":"bibr16-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(86)90058-5"},{"key":"bibr17-02841851960373P271","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.139.3.6262860"},{"key":"bibr18-02841851960373P271","first-page":"3","volume-title":"Disorders of bone and mineral metabolism","author":"Yanagawa N.","year":"1992"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851960373P271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851960373P271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:36:56Z","timestamp":1777383416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851960373P271"}},"subtitle":["Experimental Studies in Mice"],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":18,"journal-issue":{"issue":"3P2","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["10.1177\/02841851960373P271"],"URL":"https:\/\/doi.org\/10.1177\/02841851960373p271","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}