{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:51:29Z","timestamp":1777726289749,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study investigated the clinical significance of expression of caveolin-1 - a plasma membrane protein involved in caveola formation, endocytosis, signal transduction and angiogenesis - inthe pathogenesis of psoriasis vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 20 patients with psoriasis vulgaris and 20 healthy volunteers were recruited. The expressions of caveolin-1, Ki-67 (marker of cell proliferation) and CD34 (marker of angiogenesis) in skin biopsies were detected by immunohistochemistry, and the level of caveolin-1 protein was quantified by Western blotting. Clinical severity was assessed using the Psoriasis Area and Severity Index (PASI) score. Correlations between caveolin-1 expression and psoriasis severity, cell proliferation and angiogenesis were analysed using the Spearman rank correlation test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Expression of caveolin-1 was significantly lower in psoriasis samples than in healthy skin samples. In psoriasis lesions, the level of caveolin-1 expression was inversely correlated with the severity of psoriasis, cell proliferation and angiogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The level of caveolin-1 expression seems to be related to the clinical severity of psoriasis, and may play a role in the abnormal keratinocyte hyperplasia and angiogenesis seen in this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030006051204000513","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1745-1751","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Inverse Correlation between Caveolin-1 Expression and Clinical Severity in Psoriasis Vulgaris"],"prefix":"10.1177","volume":"40","author":[{"given":"WY","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DX","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00112.x"},{"key":"bibr2-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(94)00376-P"},{"key":"bibr3-030006051204000513","first-page":"417","volume":"1","author":"Traweek ST","year":"1987","journal-title":"Leukemia"},{"key":"bibr4-030006051204000513","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.91820"},{"key":"bibr5-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90143-Z"},{"key":"bibr6-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq075"},{"key":"bibr7-030006051204000513","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080873"},{"key":"bibr8-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2005.09.001"},{"key":"bibr9-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05009.x"},{"key":"bibr10-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb03819.x"},{"key":"bibr11-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.01.022"},{"key":"bibr12-030006051204000513","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.5.862"},{"key":"bibr13-030006051204000513","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.94857"},{"key":"bibr14-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.09.013"},{"key":"bibr15-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.10.2855"},{"key":"bibr16-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1080\/713803750"},{"key":"bibr17-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.32333"},{"key":"bibr18-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.04.015"},{"key":"bibr19-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22338"},{"key":"bibr20-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2005.11.007"},{"key":"bibr21-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022901"},{"key":"bibr22-030006051204000513","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.07.012"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006051204000513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/030006051204000513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030006051204000513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:58Z","timestamp":1777459558000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030006051204000513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1177\/030006051204000513"],"URL":"https:\/\/doi.org\/10.1177\/030006051204000513","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}