{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:23:44Z","timestamp":1789950224949,"version":"4.0.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study investigated levels of interleukin (IL)-34, a proinflammatory cytokine, in patients with coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Following coronary artery angiography, 91 patients with CAD (including stable and unstable angina pectoris) were divided into two groups, the CAD group (coronary artery stenosis \u2265 50%) and the control group (coronary artery stenosis &lt; 50%). Serum levels of factors including IL-34 and high sensitivity C-reactive protein (hs-CRP) were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>IL-34 and hs- CRP levels were significantly higher in the CAD group than in the control group (191.3 \u00b1 17.9 pg\/ml versus 125.4 \u00b1 14.8 pg\/ml and 3.08 \u00b1 1.81 mg\/ml versus 1.42 \u00b1 1.01 mg\/ml, respectively), with a significantly positive correlation between IL-34 and hs-CRP levels in the CAD group. Multiple regression analysis showed that IL-34 and hs-CRP levels were independent predictors of CAD (IL-34: odds ratio [OR] 2.073, 95% confidence intervals (CI) 1.419, 2.672; hs-CRP: OR 1.878, 95% CI 1.172, 2.531).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>IL-34 levels were significantly increased in patients with CAD, and positively correlated with hs- CRP levels, suggesting that IL-34 may be an independent predictor of CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030006051204000525","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1866-1870","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Increased Serum Interleukin-34 in Patients with Coronary Artery Disease"],"prefix":"10.1177","volume":"40","author":[{"given":"Zhenglong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoqun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central Hospital of Huangshi, Huangshi, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"bibr2-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"bibr3-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.18.2149"},{"key":"bibr4-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-007-0991-z"},{"key":"bibr5-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.01.009"},{"key":"bibr6-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.06.016"},{"key":"bibr7-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e3282f399e2"},{"key":"bibr8-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154370"},{"key":"bibr9-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1002\/path.2684"},{"key":"bibr10-030006051204000525","first-page":"295","volume":"35","author":"Chinese Society of Cardiology of Chinese Medical Association,","year":"2007","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"bibr11-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.08.016"},{"key":"bibr12-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.08.005"},{"key":"bibr13-030006051204000525","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1688-7"}],"container-title":["Journal of International Medical 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