{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:51:48Z","timestamp":1777726308659,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate patients with chronic hepatitis B virus (HBV) infection and low-level viraemia in terms of determining HBV DNA cut-off values and levels of alanine aminotransferase (ALT) and other possible markers for discriminating between chronic hepatitis B e-antigen (HBeAg)-negative patients and hepatitis B surface antigen (HBsAg) inactive carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>HBV-infected patients who were HBeAg-negative with undetectable HBV DNA by standard hybridization assay and high (HBeAg-negative group, n = 81) or normal (HBsAg inactive carrier group, n = 77) ALT levels were enrolled. Quantitative polymerase chain reaction assay using a COBAS Amplicor HBV monitor test was performed to detect low HBV DNA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The HBV DNA level was found to be significantly higher in the HBeAg-negative chronic HBV group (mean \u00b1 SD 94 477 \u00b1 167 528 copies\/ml) compared with the HBsAg inactive carrier group (mean \u00b1 SD 19 215 \u00b1 57 970 copies\/ml).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A low level of viral replication may persist in chronic HBV-infected patients who are HBeAg-negative, and the level of HBV DNA was higher in the HBeAg-negative group than in the inactive HBsAg carrier group. Necroinflammation also persisted in the HBeAg-negative group and these patients had a higher level of ALT than the inactive HBsAg carriers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030006051204000529","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1891-1896","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Hepatitis B Viraemia Levels in Patients with HBeAg-negative Chronic Hepatitis B Virus Infection"],"prefix":"10.1177","volume":"40","author":[{"given":"AE","family":"Atay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Baglar Hospital, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Seven","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical School of Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical School of Dicle University, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pasa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Damla Hospital, Elazig, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Degertekin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical School of Ufuk University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22884"},{"key":"bibr2-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.27834"},{"key":"bibr3-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80310-4"},{"key":"bibr4-030006051204000529","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3025"},{"key":"bibr5-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.03.006"},{"key":"bibr6-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21811"},{"key":"bibr7-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.052"},{"key":"bibr8-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00957.x"},{"key":"bibr9-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-009-9149-7"},{"key":"bibr10-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00004-1"},{"key":"bibr11-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840360617"},{"key":"bibr12-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"bibr13-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2002.00304.x"},{"key":"bibr14-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-007-9004-7"},{"key":"bibr15-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22518"},{"key":"bibr16-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07715.x"},{"key":"bibr17-030006051204000529","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21513"},{"key":"bibr18-030006051204000529","first-page":"119","volume":"92","author":"Niitsuma 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