{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:09:43Z","timestamp":1789596583488,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the efficacy of a levonorgestrel-releasing intrauterine device (LNG-IUD) as contraception for women with uterine leiomyoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty women with uterine leiomyoma requiring contraception were enrolled and had a LNG-IUD inserted. Menstrual blood volume (assessed by a pictorial blood loss assessment chart [PBAC]), haemoglobin concentration, volume of uterus and leiomyoma were determined before and after LNG-IUD insertion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The median (range) PBAC score was 145.0 (60.0 - 232.0) before LNG-IUD insertion, which significantly decreased to 44.0 (0.0 - 99.0) and 36.0 (0.0 - 90.0) after 6 and 12 months of LNG-IUD use, respectively. Prior to LNG-IUD insertion, the median haemoglobin concentration in patients with anaemia was 100.0 (69.0 - 109.0) g\/l and this increased significantly after 6 and 12 months of LNG-IUD use, to 117.5 (101.0 - 131.0) g\/l and 119.5 (108.0 - 135.0) g\/l, respectively. There were no significant changes in uterine or leiomyoma volumes. No patient became pregnant and there were no severe side-effects; one IUD was expulsed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The LNG-IUD may be a safe and effective contraceptive for women of reproductive age with uterine leiomyoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030006051204000538","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1966-1972","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Levonorgestrel-releasing Intrauterine Device is an Efficacious Contraceptive for Women with Leiomyoma"],"prefix":"10.1177","volume":"40","author":[{"given":"Z-W","family":"Xie","sequence":"first","affiliation":[{"name":"Women's Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-N","family":"Zhang","sequence":"additional","affiliation":[{"name":"Women's Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wan","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W-Z","family":"Xu","sequence":"additional","affiliation":[{"name":"Women's Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Chen","sequence":"additional","affiliation":[{"name":"Women's Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, 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