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Serological tests, imaging studies and pathological examination of the mass after surgical excision confirmed the diagnosis of isolated SCL. The second patient was a 48-year-old man with a mass (diameter 4 cm) in the right neck region for 1 month. The diagnosis of isolated SCL was made on the basis of serological tests, cervical ultrasound and pathological examination of the mass after surgical excision. Complete excision resulted in a satisfactory outcome in both patients. Isolated neck masses without associated clinical manifestations or adverse personal history are a diagnostic challenge, and SCL is easily overlooked in the differential diagnosis. Unusual masses should always remind clinicians of this infectious disease and a comprehensive diagnostic strategy is recommended. Nonroutine syphilitic serological tests should be performed in patients suspected of having SCL, and the histopathological and immunohistochemical characteristics may help to confirm the diagnosis.<\/jats:p>","DOI":"10.1177\/030006051204000541","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"1988-2000","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Isolated Syphilitic Cervical Lymphadenopathy: Report of Two Cases and Review of the Literature"],"prefix":"10.1177","volume":"40","author":[{"given":"X","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WQ","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HM","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HZ","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YM","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HY","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204163261606"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0911149"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60074-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1510"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60895-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(03)00025-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/53.3.304"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711100404"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591572001301903"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1967.00760050221022"},{"key":"e_1_3_3_12_2","first-page":"22","article-title":"Secondary syphilis misdiagnosed as a lymphoma.","volume":"112","author":"Goffinet DR","year":"1970","unstructured":"Goffinet DR, Hoyt C, Eltringham JR: Secondary syphilis misdiagnosed as a lymphoma. 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