{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:52:29Z","timestamp":1777726349594,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study investigated the association between obstructive sleep apnoea syndrome (OSAS) and flow-mediated dilatation (FMD), Rho-associated protein kinase (ROCK) activity, and C-reactive protein (CRP) concentrations in male patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive patients with symptoms suggestive of OSAS were recruited and divided into non-OSAS (n = 18) and OSAS (n = 32) groups. FMD was measured in the brachial artery; blood samples were taken to measure ROCK activity and CRP concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>ROCK activity and CRP concentrations were significantly higher, and FMD was significantly lower, in the OSAS group than in the non-OSAS group. There was a correlation between ROCK activity and FMD. In stepwise multiple regression analyses, the proportion of sleep time spent with an oxygen saturation &lt; 90% was a significant determinant of ROCK activity, while body mass index was the only significant determinant of CRP concentration. The oxygen desaturation index was a significant determinant of FMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>OSAS increased ROCK activity and was a major determinant of endothelial dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030006051204000616","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:22:55Z","timestamp":1361974975000},"page":"2183-2190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between Endothelial Dysfunction, Rho-associated Protein Kinase Activity, C-reactive Protein and Obstructive Sleep Apnoea Syndrome in Male Patients"],"prefix":"10.1177","volume":"40","author":[{"given":"L","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-H","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L-Q","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z-X","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, 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