{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:22:24Z","timestamp":1792149744344,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T00:00:00Z","timestamp":1358899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of cardiac resynchronization therapy (CRT) on collagen metabolism biomarkers and their relationship to cardiac function, in patients with ischaemic cardiomyopathy (ICM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum levels of matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP-9 (TIMP-1), carboxyterminal propeptide of type I procollagen (PICP) and carboxyterminal telopeptide of type I collagen (ICTP) were quantified before and after 12 weeks\u2019 treatment, in patients with ICM receiving CRT and standard medical therapy (CRT group) or standard medical therapy alone (non-CRT group), and in controls. Cardiac function was measured echocardiographically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MMP-9, TIMP-1, ICTP and the MMP-9\/TIMP-1 ratio were significantly higher, and the PICP\/ICTP ratio significantly lower, in patients with ICM ( n\u2009=\u200927) compared with controls ( n\u2009=\u200920). After 12 weeks\u2019 treatment, MMP-9, TIMP-1, ICTP and the MMP-9\/TIMP-1 ratio were significantly higher, and the PICP\/ICTP ratio significantly lower, in the non-CRT group ( n\u2009=\u200915) compared with the CRT group ( n\u2009=\u200912). The PICP\/ICTP ratio correlated positively with TIMP-1 and negatively with MMP-9. The early\/atrial ratio and left ventricular ejection fraction correlated positively and negatively, respectively, with the MMP-9\/TIMP-1 ratio. Echocardiographic measurements of cardiac function were significantly worse in patients with ICM compared with controls and improved significantly after treatment in the CRT group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In ICM, collagen degradation biomarkers were elevated and correlated positively with cardiac function. CRT partially reversed the deterioration in collagen metabolism and enhanced cardiac function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513475757","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T04:57:04Z","timestamp":1359003424000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Improvement in collagen metabolism after 12 weeks\u2019 cardiac resynchronization therapy in patients with ischaemic cardiomyopathy"],"prefix":"10.1177","volume":"41","author":[{"given":"Mingjiang","family":"Li","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei, China"},{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 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