{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:10:27Z","timestamp":1789236627202,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This retrospective study investigated the characteristics of secondary hyperparathyroidism (SHPT) by examining the presence of the calcium-sensing receptor (CaSR) and the rate of cell proliferation and apoptosis in parathyroid glands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen diffuse and 57 nodular hyperplastic parathyroid glands from 24 patients with SHPT were compared with 14 primary adenomas and 33 normal parathyroid glands using immunohistochemical staining of CaSR and a marker of proliferative activity (Ki67 antigen). Apoptosis was measured using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean\u2009\u00b1\u2009SE labelling index (LI) of CaSR (12.8%\u2009\u00b1\u20091.5%) in nodular hyperplasia was significantly lower than that in normal parathyroid glands (26.8%\u2009\u00b1\u20090.8%), whereas the mean\u2009\u00b1\u2009SE LI of CaSR in diffuse hyperplasia was similar to that in normal parathyroid glands (23.3%\u2009\u00b1\u20091.8%). The mean\u2009\u00b1\u2009SE LI of Ki67 antigen was significantly higher in primary adenoma and nodular hyperplasia than in normal parathyroid glands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicate that downregulation of CaSR, and a higher rate of proliferation over apoptosis, could contribute to the pathological progression of SHPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513476600","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T21:56:36Z","timestamp":1359410196000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism"],"prefix":"10.1177","volume":"41","author":[{"given":"Hye-Jeong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U-Hyoung","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Uk","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Bok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Korea University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"bibr1-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706183162504"},{"key":"bibr2-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2000.00370.x"},{"key":"bibr3-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234914"},{"key":"bibr4-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119359"},{"key":"bibr5-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00302.2004"},{"key":"bibr6-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.41"},{"key":"bibr7-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026570518919"},{"key":"bibr8-0300060513476600","doi-asserted-by":"crossref","unstructured":"Parfitt AM: Parathyroid growth: normal and abnormal. In:\n                      The Parathyroids: Basic and Clinical Concepts\n                      , 2nd edn (Bilezikian JP, Marcus R, Levine MA, eds). San Diego: Academic Press, 2001; pp 293\u2013329.","DOI":"10.1016\/B978-012098651-4\/50020-1"},{"key":"bibr9-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1053\/jarr.2002.34846"},{"key":"bibr10-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00161.x"},{"key":"bibr11-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2008.00594.x"},{"key":"bibr12-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199607000-00008"},{"key":"bibr13-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00027.x"},{"key":"bibr14-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.61.s80.26.x"},{"key":"bibr15-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00986.x"},{"key":"bibr16-0300060513476600","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.1.18"},{"key":"bibr17-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00863.x"},{"key":"bibr18-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1161141"},{"key":"bibr19-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1309\/9NXP7FRF87MU2PCK"},{"key":"bibr20-0300060513476600","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06040710"},{"key":"bibr21-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.057273"},{"key":"bibr22-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V115903"},{"key":"bibr23-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031633"},{"key":"bibr24-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01684.x"},{"key":"bibr25-0300060513476600","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01040308"},{"key":"bibr26-0300060513476600","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03630509"},{"key":"bibr27-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq725"},{"key":"bibr28-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm177"},{"key":"bibr29-0300060513476600","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0547-5"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060513476600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060513476600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060513476600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:46Z","timestamp":1777459906000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060513476600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,28]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1177\/0300060513476600"],"URL":"https:\/\/doi.org\/10.1177\/0300060513476600","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,28]]}}}