{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:25:38Z","timestamp":1777728338340,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effects of glutamate receptor, ionotropic, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) 2 ( GRIA2) rs4260586 and glutamate receptor, ionotropic, AMPA 4 ( GRIA4) rs10736648 single nucleotide polymorphisms (SNPs) on response to antidepressants in Korean patients with major depressive disorder (MDD), and to ascertain whether epistatic interactions might exist between these SNPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective analysis, patients were assessed at hospital admission and discharge using the Montgomery\u2013\u00c5sberg depression rating scale (MADRS). A multiple regression model was employed to investigate the effects of the two SNP variants on clinical\/sociodemographic outcomes relating to MDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 145 Korean patients, the presence of both GRIA2 rs4260586 and GRIA4 rs10736648 polymorphisms had no significant association with MADRS improvement scores or other clinical\/sociodemographic variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data potentially suggest a lack of epistatic interaction between GRIA2 and GRIA4 variants, regarding clinical outcomes in patients with MDD. The study was limited by small sample size, use of different antidepressants and incomplete coverage of genes under investigation. Future research should include larger patient samples treated with different antidepressants, analysis of different SNPs and\/or investigation of different gene\u2013gene interactions within the glutamatergic system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513477295","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T22:22:18Z","timestamp":1366064538000},"page":"809-815","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigation of possible epistatic interactions between\n                    <i>GRIA2<\/i>\n                    and\n                    <i>GRIA4<\/i>\n                    variants on clinical outcomes in patients with major depressive disorder"],"prefix":"10.1177","volume":"41","author":[{"given":"Alberto","family":"Chiesa","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"},{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Lia","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Lia","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bucheon St Mary\u2019s Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyounggi-Do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin A","family":"Patkar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Un","family":"Pae","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bucheon St Mary\u2019s Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyounggi-Do, Republic of Korea"},{"name":"Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"bibr1-0300060513477295","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"bibr2-0300060513477295","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra073096"},{"key":"bibr3-0300060513477295","first-page":"83","volume":"30","author":"Kato M","year":"2010","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"bibr4-0300060513477295","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.5.780"},{"key":"bibr5-0300060513477295","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-007-0063-1"},{"key":"bibr6-0300060513477295","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1407"},{"key":"bibr7-0300060513477295","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.250"},{"key":"bibr8-0300060513477295","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.08.011"},{"key":"bibr9-0300060513477295","unstructured":"Fabbri C, Drago A and Serretti A. 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