{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:58:05Z","timestamp":1793876285332,"version":"4.7.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the expression of interleukin (IL) 17A in Chinese patients with chronic rhinosinusitis (CRS) and analyse its correlation with clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing functional endoscopic sinus surgery and matched controls were included in this retrospective study. Clinical assessments (using a visual analogue scale of symptom severity, Johansson endoscopic score and Lund\u2013Mackay computed tomography score) were performed preoperatively. Mucosal specimens were analysed for inflammatory infiltration and IL-17A expression, using immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 40 patients undergoing functional endoscopic sinus surgery and 16 controls were included in the study. IL-17A levels were significantly higher in tissues from patients with CRS (with or without nasal polyps) than in control tissues. In CRS, IL-17A expression tended to be higher in tissues with infiltrating neutrophils than in those with infiltrating eosinophils, but this difference was not significant. IL-17A expression in CRS was positively correlated with symptom severity, endoscopic findings and radiological appearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Expression of IL-17A was higher in Chinese patients with CRS than in controls, and was associated with infiltrating inflammatory cells, symptom severity, endoscopic findings and radiological appearance. These findings suggest that IL-17A may play a role in CRS pathogenesis and remodelling of nasal polyps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513478089","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T22:38:14Z","timestamp":1366324694000},"page":"777-784","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Interleukin-17A expression in patients with chronic rhinosinusitis and its relationship with clinical features"],"prefix":"10.1177","volume":"41","author":[{"given":"Xi-Dong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, People\u2019s Hospital of Deqing County, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Yang","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, First Affiliated Hospital, Zhejiang University Faculty of Medicine, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, First Affiliated Hospital, Zhejiang University Faculty of Medicine, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Tian","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology, First Affiliated Hospital, Zhejiang University Faculty of Medicine, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ying","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pathology, People\u2019s Hospital of Deqing County, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Xian","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, People\u2019s Hospital of Deqing County, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, People\u2019s Hospital of Deqing County, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,4,18]]},"reference":[{"key":"bibr1-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.029"},{"key":"bibr2-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0249-4"},{"key":"bibr3-0300060513478089","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-RAI-0202"},{"key":"bibr4-0300060513478089","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3680"},{"key":"bibr5-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"bibr6-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.014"},{"key":"bibr7-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1159\/000232566"},{"key":"bibr8-0300060513478089","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3645"},{"key":"bibr9-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.008"},{"key":"bibr10-0300060513478089","first-page":"1","volume":"45","author":"Fokkens W","year":"2007","journal-title":"Rhinol Suppl"},{"key":"bibr11-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1080\/000164800760370873"},{"key":"bibr12-0300060513478089","first-page":"183","volume":"107","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"bibr13-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"bibr14-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.072"},{"key":"bibr15-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"bibr16-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00628.x"},{"key":"bibr17-0300060513478089","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.R-07-160"},{"key":"bibr18-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.017"},{"key":"bibr19-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00027"},{"key":"bibr20-0300060513478089","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1557"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060513478089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060513478089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060513478089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:51Z","timestamp":1777459911000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060513478089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,18]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1177\/0300060513478089"],"URL":"https:\/\/doi.org\/10.1177\/0300060513478089","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,18]]}}}