{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:25:52Z","timestamp":1777728352425,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Autism spectrum disorders (ASD) are a family of childhood-onset neurodevelopmental disorders with complex genetic mechanisms underlying their aetiology. The aim of this case\u2013control study was to evaluate the effect of the catechol-O-methyltransferase ( COMT) gene Val158Met polymorphism on ASD risk in a Chinese Han population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The COMT gene Val158Met polymorphism was detected by polymerase chain reaction\u2013restriction fragment length polymorphism in children (\u226418 years old) with ASD and healthy control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequency of the Val158\/Val158 genotype in children with ASD (22\/186; 11.8%) was significantly lower than in controls (38\/186; 20.4%). When stratifying by select-item scores on the Autism Diagnostic Interview-Revised protocol, it was found that children with \u2018current overactivity\u2019 and \u2018ever overactivity\u2019 had a significantly lower frequency of the Val158\/Val158 genotype than those without. There were no significant associations between the COMT gene Val158Met polymorphism and ASD subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The COMT gene Val158Met polymorphism may be a biomarker for phenotypic variation in ASD, but these preliminary findings remain tentative, pending replication in larger, independent samples.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513479871","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T22:22:18Z","timestamp":1366064538000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Catechol-O-methyltransferase Val158Met polymorphism and risk of autism spectrum disorders"],"prefix":"10.1177","volume":"41","author":[{"given":"Tianyou","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Psychology, Normal College, Shenzhen University, Shenzhen, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, First Affiliated Hospital of WenZhou Medical College, WenZhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychology, WenZhou Medical College, WenZhou, Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, First Affiliated Hospital of WenZhou Medical College, WenZhou, Zhejiang Province, 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