{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:20:56Z","timestamp":1778239256269,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify the effects of two years\u2019 oral bisphosphonate (alendronate) treatment in patients who underwent total knee arthroplasty (TKA); to determine whether significant responses seen after the first year of treatment changed during the second year. Additionally, the study tried to identify factors relating to bone mineral density (BMD) changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective 2-year follow-up study of a previous 1-year report of postmenopausal women with knee osteoarthritis who underwent primary unilateral or staged bilateral TKA, after which they received 70\u2009mg alendronate orally once-weekly. BMD was measured using quantitative computed tomography (QCT) on lumbar vertebrae at baseline (pre-TKA) and at 12 and 24 months. Factors associated with BMD changes were determined by regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-one patients entered the second year and continued treatment for \u226524 months. Mean vertebral QCT BMDs at baseline and after 12 and 24 months\u2019 alendronate treatment were 71.8\u2009mg\/ml (41.9\u201397.5\u2009mg\/ml), 69.3\u2009mg\/ml (31.4\u2013103.9\u2009mg\/ml), and 72.7\u2009mg\/ml (33.1\u2013136.1\u2009mg\/ml), respectively. Patients undergoing bilateral TKA and who had more severe OA at baseline (bilateral severe [grade 4] OA) had a lower BMD response after 2 years\u2019 bisphosphonate treatment, compared with patients with less severe unilateral knee OA who underwent unilateral TKA. Improvements were, however, seen compared with year 1 levels. Low BMI was associated with BMD nonresponse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with bilateral severe OA (grade 4) requiring bilateral knee replacement are at greater risk of nonresponse after 2 years\u2019 oral alendronate treatment. A longer duration of treatment may be necessary in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513480090","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T23:08:54Z","timestamp":1368745734000},"page":"878-888","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Quantitative computed tomography assessment of bone mineral density after 2 years\u2019 oral bisphosphonate treatment in postmenopausal osteoarthritis patients who underwent total knee arthroplasty"],"prefix":"10.1177","volume":"41","author":[{"given":"Jin Kyu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Hanyang University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong H","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Hanyang University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Nam","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Hanyang University College of Medicine, Seoul, Republic of 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