{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:24:32Z","timestamp":1780759472464,"version":"3.54.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the value of D-dimer and protein S plasma concentrations for diagnosis of portal vein thrombosis (PVT) in patients with liver cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>D-dimer and protein S were quantified, PVT was diagnosed by dynamic enhanced computed tomography and liver function was classified using the Child\u2013Pugh system. Receiver operating curve analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>D-dimer increased, and protein S decreased, with decreasing liver function in the total study population ( n\u2009=\u2009188). D-dimer concentrations were significantly higher and protein S concentrations were significantly lower in patients with ( n\u2009=\u200951) than those without PVT ( n\u2009=\u2009137). D-dimer had high specificity and negative predictive value (NPV) in Child\u2013Pugh class A or B patients (cut-off values&gt;0.56\u2009mg\/l and &gt;1.18\u2009mg\/l, respectively). In class C patients&gt;0.77\u2009mg\/l D-dimer had high sensitivity and NPV. Protein S had high sensitivity but low specificity in class A or B patients (cut-off values\u2009&lt;\u200917.4\u2009mg\/l and &lt;19.2\u2009mg\/l, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma D-dimer and protein S are potential biomarkers for PVT diagnosis in patients with cirrhosis. PVT can be excluded when D-dimer is low and protein S is elevated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513483413","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T04:55:46Z","timestamp":1367470546000},"page":"664-672","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Value of D-dimer and protein S for diagnosis of portal vein thrombosis in patients with liver cirrhosis"],"prefix":"10.1177","volume":"41","author":[{"given":"Dong-Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Beijing Chao-yang Hospital Affiliate of Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Yu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Chao-yang Hospital Affiliate of Capital Medical University, 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