{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:27:21Z","timestamp":1777728441050,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>We report a case of primary empty sella syndrome (ESS) resulting in osteoporotic fractures and persistent non-fusion of the hand epiphyses, and discuss the potential pathogenesis of this disease. A 41-year-old man presented with pain in the right hand and back after a fall. X-radiographs revealed persistent epiphyses and severe osteoporosis. Serum phosphorus and prolactin levels were above normal levels, and free triiodothyronine, free thyroxine and testosterone levels were below normal limits. Magnetic resonance imaging of the head revealed empty sella. A lumbar bone mineral density examination indicated severe osteoporosis. ESS caused a systemic hormone disorder in this patient, resulting in osteoporotic fractures and persistent non-fusion of the hand epiphyses. Possible causes of this anomaly are chronic or congenital abnormities of the pituitary gland.<\/jats:p>","DOI":"10.1177\/0300060513490609","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T01:04:08Z","timestamp":1379034248000},"page":"1768-1772","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Osteoporotic fractures and persistent non-fusion of the hand epiphyses caused by empty sella syndrome in an adult: A case report"],"prefix":"10.1177","volume":"41","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Shanghai Children\u2019s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunrong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400210140024"},{"key":"e_1_3_2_3_2","first-page":"233","article-title":"[Primary empty sella syndrome. 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