{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:15:37Z","timestamp":1783397737755,"version":"3.54.6"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Nosocomial infection caused by carbapenem-resistant Acinetobacter baumannii is a worldwide problem and treatment options remain controversial. This study investigated the in\u00a0vitro effect of various antibiotic combinations against carbapenem-resistant A. baumannii strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Antibiotic susceptibility of A. baumannii strains was analysed. In\u00a0vitro synergistic efficacy of colistin combined with tigecycline, cefoperazone\/sulbactam or piperacillin\/tazobactam was tested against carbapenem-resistant A. baumannii strains. Synergy studies were performed using an eplisometer test-strip method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 50 carbapenem-resistant A. baumannii strains tested, 96% were susceptible to colistin and 64% were susceptible to tigecycline. Colistin\u2013tigecycline, colistin\u2013cefoperazone\/sulbactam and colistin\u2013piperacillin\/tazobactam combinations were found to have synergistic effects against six (12%), two (4%), and one (2%), respectively, of the strains tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Colistin combined with tigecycline, cefoperazone\/sulbactam or piperacillin\/tazobactam revealed synergistic effects in some carbapenem-resistant A. baumannii strains. These results, together with the shortage of treatment options and the risk of developing resistance to colistin, suggest that clinicians should use colistin combined with other antibiotics or \u03b2-lactamase inhibitors when treating carbapenem-resistant A. baumannii infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513496172","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T10:19:00Z","timestamp":1385029140000},"page":"1830-1837","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["<i>In\u00a0vitro<\/i>\n                    synergistic activity of colistin with tigecycline or \u03b2-lactam antibiotic\/\u03b2-lactamase inhibitor combinations against carbapenem-resistant\n                    <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1177","volume":"41","author":[{"given":"Ilkay","family":"Karaoglan","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Zer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuslat Kecik","family":"Bosnak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Ozlem","family":"Mete","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Nam\u0131duru","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"bibr1-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1159\/000321018"},{"key":"bibr2-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200308000-00003"},{"key":"bibr3-0300060513496172","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-11-200206040-00013"},{"key":"bibr4-0300060513496172","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.68538"},{"key":"bibr5-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(10)70004-2"},{"key":"bibr6-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-07"},{"key":"bibr7-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/002469-0"},{"key":"bibr8-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03115.x"},{"key":"bibr9-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(95)00020-B"},{"key":"bibr10-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1086\/340055"},{"key":"bibr11-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1086\/653120"},{"key":"bibr12-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.2.448"},{"key":"bibr13-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2002.00415.x"},{"key":"bibr14-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.8.1099"},{"key":"bibr15-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L171"},{"key":"bibr16-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01464-06"},{"key":"bibr17-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-8-18"},{"key":"bibr18-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1086\/647952"},{"key":"bibr19-0300060513496172","unstructured":"Clinical and Laboratory Standards Institute. 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Synergy testing by Etest, microdilution checkerboerd, and time kill methods for pan drug resistant Acinetobacter baumannii.\n                      Antimicrob Agents Chemother\n                      2010; 4678\u20134683.","DOI":"10.1128\/AAC.00497-10"},{"key":"bibr34-0300060513496172","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0330-4"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060513496172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060513496172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060513496172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:52Z","timestamp":1777459612000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060513496172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1177\/0300060513496172"],"URL":"https:\/\/doi.org\/10.1177\/0300060513496172","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]}}}