{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:35:33Z","timestamp":1790872533256,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate changes in standard base excess (SBE) when administering two different infusion regimens for elective hip replacement within a goal-directed haemodynamic algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, double-blind, randomized, controlled study enrolled patients scheduled for primary hip replacement surgery, who were randomized to receive either an unbalanced crystalloid (chloride: 155.5\u2009mmol\/l) or a 1\u2009:\u20091 mixture of a balanced crystalloid and a balanced colloid (6% w\/v hydroxyethyl starch 130\/0.42; chloride: 98 and 112\u2009mmol\/l, respectively). Fluid management was goal-directed to optimize stroke volume using oesophageal Doppler.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 40 patients (19 female\/21 male) participated in the study. After surgery, median (25\u201375% percentiles) SBE was significantly lower in the unbalanced group compared with the balanced group: \u22122.0\u2009mmol\/l (\u22123.1 to \u22121.1) versus \u22120.4\u2009mmol\/l (\u22121.2 to 0.7), respectively. This difference was mainly due to greater plasma chloride concentrations in the unbalanced group. The amount of study medication required to reach haemodynamic stability (median 1200\u2009ml) did not differ between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SBE decreased in the unbalanced group without influence on fluid requirements and haemodynamic stability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060513509548","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T23:02:11Z","timestamp":1392073331000},"page":"468-486","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of goal-directed therapy with balanced crystalloid\u2013colloid or unbalanced crystalloid solution on base excess"],"prefix":"10.1177","volume":"42","author":[{"given":"Holger","family":"Krebbel","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte and Campus Charit\u00e9 Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarne","family":"Feldheiser","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte and Campus Charit\u00e9 Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte and Campus Charit\u00e9 Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willehad","family":"Boemke","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte and Campus Charit\u00e9 Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte and Campus Charit\u00e9 Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Perka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Dieter","family":"Wernecke","sequence":"additional","affiliation":[{"name":"SOSTANA GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Spies","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte and Campus Charit\u00e9 Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60878-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61148-9"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323001204000402"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(71)90474-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9230"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1990.01410160084019"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199209000-00014"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199611000-00001"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200115020-00001"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1994.tb04450.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199602000-00044"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199905000-00007"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03901.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430040041005"},{"key":"e_1_3_4_16_2","first-page":"CD000567","article-title":"Colloids versus crystalloids for fluid resuscitation in critically ill patients","author":"Perel P","year":"2011","unstructured":"Perel P, Roberts I. 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