{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:29:09Z","timestamp":1777728549505,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5\u2009mg\/kg), 0.03\u2009mg\/kg cisatracurium or 0.15\u2009mg\/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30\u2009s, followed by propofol (0.5\u2009mg\/kg). Pain was evaluated using a four-point scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence and severity of pain was significantly lower in the lidocaine and 0.15\u2009mg\/kg cisatracurium groups than the control and 0.03\u2009mg\/kg cisatracurium groups (n\u2009=\u200950\/group). There was no significant difference between the lidocaine and 0.15\u2009mg\/kg cisatracurium groups in the incidence and severity of pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>0.15\u2009mg\/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060514522602","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T22:51:51Z","timestamp":1393455111000},"page":"360-367","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial"],"prefix":"10.1177","volume":"42","author":[{"given":"Yun-Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Pain Medicine, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Namgung","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Medicine, College of Medicine, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Hak","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Medicine, College of Medicine, Korea University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199550040-00006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.3.247"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199905000-00023"},{"key":"e_1_3_3_5_2","first-page":"543","article-title":"Premixing lidocaine reduces the incidence and severity of pain on injection of propofol","volume":"46","author":"Inoue S","year":"1997","unstructured":"Inoue S, Mitsuhata H, Shimizu R, et al. Premixing lidocaine reduces the incidence and severity of pain on injection of propofol. Masui 1997; 46: 543\u2013546. [in Japanese, English Abstract].","journal-title":"Masui"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199202000-00013"},{"key":"e_1_3_3_7_2","first-page":"8","article-title":"Incidence of pain on propofol injection and efficacy of addition of lignocaine or selecting big vein or both combined in reducing it: a randomized control trial","volume":"20","author":"Tariq MA","year":"2006","unstructured":"Tariq MA, Kamran M. Incidence of pain on propofol injection and efficacy of addition of lignocaine or selecting big vein or both combined in reducing it: a randomized control trial. 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Effect of pretreatment with lidocaine, intravenous paracetamol and lidocaine-fentanyl on propofol injection pain. Comparative study. Rev Bras Anestesiol 2007; 57: 32\u201338. 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