{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:29:16Z","timestamp":1777728556177,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:00:00Z","timestamp":1402531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Objective<\/jats:title>\n \n To compare the treatment effects of Novolin\u00ae 30R\n a<\/jats:sup>\n , versus Lantus\n \u00aea<\/jats:sup>\n combined with acarbose (Glucobay\u00ae), in elderly patients with type 2 diabetes mellitus.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients (aged\u2009>\u200960 years) with type 2 diabetes mellitus were randomized to receive either Novolin\u00ae 30R\n a<\/jats:sup>\n (initial dose 0.5\u2009IU\/kg) or Lantus\n \u00aea<\/jats:sup>\n (initial dose 0.2\u2009IU\/kg) combined with 50\u2009mg acarbose. After a 32-week treatment period, the following parameters were measured: blood glucose control; blood lipid levels; body mass index; proportion of patients achieving a glycosylated haemoglobin (HbA\n 1c<\/jats:sub>\n ) level <7.5%; rate of hypoglycaemic events; change in fasting blood glucose levels from baseline in patients stratified according to their baseline HbA\n 1c<\/jats:sub>\n level.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 188 patients were enrolled in the study. After 32 weeks\u2019 treatment, compared with baseline levels, there were significant reductions in FBG, 2\u2009h-postprandial blood glucose during an oral glucose tolerance test, HbA\n 1c<\/jats:sub>\n , total cholesterol, triglycerides and low-density lipoprotein cholesterol values in both groups. Although there were fewer hypoglycaemic events in the Lantus\u00ae combined with Glucobay\u00ae group compared with the Novolin\u00ae 30R group, the difference was not significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Novolin\u00ae 30R and Lantus\u00ae combined with acarbose both had beneficial effects on blood glucose control and blood lipid levels in elderly patients with type 2 diabetes mellitus.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0300060514529555","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T03:45:47Z","timestamp":1402631147000},"page":"993-1001","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical effectiveness of Novolin\u00ae 30R versus Lantus\u00ae combined with Glucobay\u00ae treatment in elderly patients with type 2 diabetes mellitus controlled by oral hypoglycaemic agents: A randomized study"],"prefix":"10.1177","volume":"42","author":[{"given":"Yixuan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianping","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianli","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 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