{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:41:41Z","timestamp":1789389701851,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of salidroside on cognitive dysfunction induced by chronic cerebral hypoperfusion in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Sprague\u2013Dawley rats ( n\u2009=\u200936) were divided into three groups ( n\u2009=\u200912 per group): sham operation; bilateral permanent occlusion of the common carotid arteries (2-VO); 2-VO\u2009+\u2009salidroside. Rats received 20\u2009mg\/kg per day salidroside or vehicle intraperitoneal injection beginning the day before surgery and continuing until 34 days postoperatively. Cognitive function was evaluated by Morris water maze test and hippocampal long-term potentiation (LTP) measurement. Hippocampal neuronal apoptosis was evaluated via immunofluorescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chronic cerebral hypoperfusion caused marked cognitive deficit and LTP inhibition. These effects were largely ameliorated by salidroside administration. Salidroside prevented caspase-3 activation, increased the ratio of Bax\/Bcl-2, and reversed hippocampal neuronal loss induced by chronic cerebral hypoperfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Salidroside prevents cognitive deficits caused by chronic cerebral hypoperfusion in rats, and alleviates apoptosis in the hippocampal CA1 area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060514566648","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T21:32:31Z","timestamp":1428615151000},"page":"402-411","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Salidroside prevents cognitive impairment induced by chronic cerebral hypoperfusion in rats"],"prefix":"10.1177","volume":"43","author":[{"given":"Zhi-Qiang","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an, China"},{"name":"Department of Neurosurgery, Urumqi General Hospital of Lanzhou Military Command, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Encephalopathy, Traditional Chinese Medicine Hospital of Shan Xi Province, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Xiang","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Urumqi General Hospital of Lanzhou Military Command, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Guo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Urumqi General Hospital of Lanzhou Military Command, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Hong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, The Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, K. 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Leung Brain Research Centre, The Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"bibr1-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70169-8"},{"key":"bibr2-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.09.014"},{"key":"bibr3-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.02.037"},{"key":"bibr4-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.05.023"},{"key":"bibr5-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.02.002"},{"key":"bibr6-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.58.1627"},{"key":"bibr7-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.03.009"},{"key":"bibr8-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.01.046"},{"key":"bibr9-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.02.040"},{"key":"bibr10-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/679635"},{"key":"bibr11-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-3988(09)60062-3"},{"key":"bibr12-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.06.021"},{"key":"bibr13-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045763"},{"key":"bibr14-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.11.062"},{"key":"bibr15-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3185-7"},{"key":"bibr16-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.12.006"},{"key":"bibr17-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.11.080"},{"key":"bibr18-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90394-8"},{"key":"bibr19-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00067-4"},{"key":"bibr20-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10101"},{"key":"bibr21-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-014-1164-8"},{"key":"bibr22-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.09.017"},{"key":"bibr23-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"bibr24-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07550.x"},{"key":"bibr25-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.038"},{"key":"bibr26-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4841"},{"key":"bibr27-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400593"},{"key":"bibr28-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1038\/nrc883"},{"key":"bibr29-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.10.006"},{"key":"bibr30-0300060514566648","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-009-0177-3"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060514566648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060514566648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060514566648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:52:45Z","timestamp":1777459965000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060514566648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1177\/0300060514566648"],"URL":"https:\/\/doi.org\/10.1177\/0300060514566648","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,9]]}}}