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The role of NSAIDs is less clear in the treatment of conditions involving soft tissue inflammation, including the airways, ear\u2013nose\u2013throat (ENT) system and urogenital tract. These conditions are often treated inappropriately with antibiotics. Morniflumate, the \u00df-morpholinoethyl ester of niflumic acid, is a member of the fenamate family of NSAIDs indicated for the treatment of inflammatory conditions (with or without pain) affecting airways, the ENT system, urogenital tract and the osteoarticular system. Morniflumate has a 30-year history of clinical use, particularly for the treatment of pain associated with paediatric ENT infection. This article reviews evidence supporting the efficacy and safety of morniflumate. Based on available evidence and the favourable tolerability profile emerging from extensive clinical use, morniflumate appears to be a valid and well-tolerated alternative to other NSAIDs, or to antibiotics, for the treatment of pain and other symptoms of soft tissue inflammation.<\/jats:p>","DOI":"10.1177\/0300060514567212","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T22:01:46Z","timestamp":1430258506000},"page":"290-302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and Safety of Morniflumate for the Treatment of Symptoms Associated with Soft Tissue Inflammation"],"prefix":"10.1177","volume":"43","author":[{"given":"Giovanni","family":"Cremonesi","sequence":"first","affiliation":[{"name":"Chiesi Farmaceutici S.p.A, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"Chiesi Farmaceutici S.p.A, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"bibr1-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7086"},{"key":"bibr2-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2263-6"},{"key":"bibr3-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.08.005"},{"key":"bibr4-0300060514567212","doi-asserted-by":"publisher","DOI":"10.18433\/J3VW2F"},{"key":"bibr5-0300060514567212","first-page":"142","volume":"6","author":"Nouri ME","year":"1984","journal-title":"Clin Ther"},{"key":"bibr6-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.215"},{"key":"bibr7-0300060514567212","first-page":"541","volume":"46","author":"Benarrosh C","year":"1989","journal-title":"Arch Fr Pediatr"},{"key":"bibr8-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)80205-7"},{"key":"bibr9-0300060514567212","first-page":"133","volume":"48","author":"Conti M","year":"1997","journal-title":"Acta Otorrinolaringol Esp"},{"key":"bibr10-0300060514567212","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199917010-00001"},{"key":"bibr11-0300060514567212","first-page":"817","volume":"50","author":"Thomas M","year":"2000","journal-title":"Br J Gen Pract"},{"key":"bibr12-0300060514567212","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1742-1241.2002.tb11366.x","volume":"56","author":"Moore N","year":"2002","journal-title":"Int J Clin Pract"},{"key":"bibr13-0300060514567212","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200323040-00006"},{"key":"bibr14-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.6.521"},{"key":"bibr15-0300060514567212","first-page":"557","volume":"58","author":"de Mey C","year":"2008","journal-title":"Arzneimittelforschung"},{"key":"bibr16-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M332"},{"key":"bibr17-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1177\/147323000203000212"},{"key":"bibr18-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.12.014"},{"key":"bibr19-0300060514567212","first-page":"293","volume":"60","author":"Frye R","year":"2011","journal-title":"J Fam Pract"},{"issue":"1","key":"bibr20-0300060514567212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-0691.2011.03702.x","volume":"18","author":"ESCMID Sore Throat Guideline Group, Pelucchi C","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"bibr21-0300060514567212","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp13X663118"},{"key":"bibr22-0300060514567212","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.11.001"},{"key":"bibr23-0300060514567212","unstructured":"Snellman L, Adams W, Anderson G, et\u00a0al. 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