{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:46:40Z","timestamp":1777726000534,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of long-term treatment with bosentan on pulmonary arterial hypertension (PAH) in patients with systemic sclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with systemic sclerosis were followed between 2003 and 2014; those who developed digital ulcers were treated with standard regimens of bosentan. Patients were assessed at baseline and every 12\u2009months using transthoracic Doppler echocardiography, 6-min walking distance test, Borg dyspnoea index and monitoring of plasma levels of 76-amino-acid N-terminal probrain natriuretic peptide. Patients who developed PAH underwent right heart catheterization to confirm the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-nine patients with systemic sclerosis were enrolled in the study. Of these, 25 developed digital ulcers and received treatment with bosentan; the remaining 44 comprised the control group. None of the patients treated with bosentan developed PAH during the follow-up period. Furthermore, in these patients the mean\u2009\u00b1\u2009SD systolic pulmonary arterial pressure significantly decreased from 33.64\u2009\u00b1\u20092.91\u2009mmHg at baseline to 26.20\u2009\u00b1\u20091.78\u2009mmHg at the end of the follow-up period. In contrast, in the control group, seven patients developed PAH during the follow-up period, with the mean\u2009\u00b1\u2009SD systolic pulmonary arterial pressure significantly increasing from 33.57\u2009\u00b1\u20092.75\u2009mmHg at baseline to 39.41\u2009\u00b1\u20094.11\u2009mmHg at the end of the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term treatment with bosentan reduces the risk of developing PAH in patients with systemic sclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060515593257","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T21:17:38Z","timestamp":1475356658000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Beneficial effects of long-term treatment with bosentan on the development of pulmonary arterial hypertension in patients with systemic sclerosis"],"prefix":"10.1177","volume":"44","author":[{"given":"Giuseppe","family":"Murdaca","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Clinical Immunology Unit, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Lantieri","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Biostatistics Unit, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Puppo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Immunology Unit, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Paolo","family":"Bezante","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manrico","family":"Balbi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"bibr1-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(03)00024-3"},{"key":"bibr2-0300060515593257","first-page":"S19","volume":"22","author":"Kahaleh MB","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"bibr3-0300060515593257","doi-asserted-by":"publisher","DOI":"10.2174\/1570161112666140226122054"},{"key":"bibr4-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.079921"},{"key":"bibr5-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.096677"},{"key":"bibr6-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2396"},{"key":"bibr7-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"bibr8-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"bibr9-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2172-z"},{"key":"bibr10-0300060515593257","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328332bcdb"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060515593257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060515593257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060515593257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:31Z","timestamp":1777459471000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060515593257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":10,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1177\/0300060515593257"],"URL":"https:\/\/doi.org\/10.1177\/0300060515593257","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}