{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:34:37Z","timestamp":1777728877628,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the efficacy and prognosis of autologous hematopoietic stem cell transplantation (ASCT) as frontline treatment for peripheral T cell lymphoma (PTCL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data from 46 PTCL patients who achieved complete (CR) or partial remission (PR) after ASCT from October 1996 to July 2014 were analysed retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median patient age was 32 (range: 15\u201368) years. Disease types included PTCL, unspecified type, in 23 patients, anaplastic large cell lymphoma in eight, angioimmunoblastic lymphoma in eight, extranodal NK\/T-cell lymphoma in five, and hepatosplenic T-cell lymphoma and enteropathy associated T-cell lymphoma in one each. Of these patients, 80% had Prognostic Index for Peripheral T-cell Lymphoma scores \u22651. Thirty-four patients had pre-transplantation CR and 12 had PR. Median follow up was 37 (6\u2013176) months. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 77.1% and 61.9%, respectively. Multivariate analysis showed that pre-transplantation CR was an independent risk factor for survival, and CR was more common than PR (OS 81% vs 59.3%; PFS 71.8% vs 17.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Frontline consolidation treatment with ASCT was associated with favourable outcomes in patients with PTCL. Pre-transplantation CR was a prognostic factor for survival, suggesting that ASCT may be favoured as front-line consolidation therapy after first complete remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060516676725","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T04:31:40Z","timestamp":1484195500000},"page":"290-302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Autologous stem cell transplantation as frontline strategy for peripheral T-cell lymphoma: A single-centre experience"],"prefix":"10.1177","volume":"45","author":[{"given":"Xiao","family":"Han","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daobin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ruan","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Duan","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tienan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huacong","family":"Cai","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Cao","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqi","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH), Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"bibr1-0300060516676725","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-231548"},{"key":"bibr2-0300060516676725","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.07.010"},{"key":"bibr3-0300060516676725","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"bibr4-0300060516676725","unstructured":"Swerdlow SH, Campo E, Harris NL, et al.\n                      WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues\n                      . 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