{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:35:05Z","timestamp":1777728905281,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>A case of laryngeal myasthenia gravis in a 65-year-old woman presenting with hoarseness as the sole symptom is reported. Voice spectrography was performed before and after injection of intravenous edrophonium. There was a marked improvement in the patient\u2019s voice after the administration of edrophonium, which was confirmed by the changes seen on the sound spectrogram. This was the only objective indication of a diagnosis of myasthenia gravis. No thymoma was seen on chest X-ray and the patient was negative for anti-acetylcholine receptor antibodies. Treatment for laryngeal myasthenia gravis was initiated and the patient\u2019s vocal problems resolved. This case emphasizes the need to consider systemic diseases in the differential diagnosis of hoarseness and demonstrates the need for careful follow-up in such patients.<\/jats:p>","DOI":"10.1177\/0300060516685026","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T19:08:46Z","timestamp":1485803326000},"page":"1466-1469","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Detectable voice change with the edrophonium test in laryngeal myasthenia gravis"],"prefix":"10.1177","volume":"45","author":[{"given":"Koichi","family":"Tsunoda","sequence":"first","affiliation":[{"name":"National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Fujimaki","sequence":"additional","affiliation":[{"name":"National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"bibr1-0300060516685026","doi-asserted-by":"crossref","unstructured":"Fujimaki Y, Tsunoda K, Kobayashi R, et\u00a0al. Independent exercise for glottal incompetence to improve vocal problems and prevent aspiration pneumonia in the elderly: a randomized controlled trial.\n                      Clin Rehabil\n                      Epub ahead of print 14 October 2016. 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