{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:35:27Z","timestamp":1777728927881,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess possible changes in leptin and ghrelin secretion due to etanercept in juvenile idiopathic arthritis (JIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>50 patients with JIA and 16 age-matched controls were enrolled into this prospective, cross-sectional study. Serum leptin, total and acyl ghrelin were measured in addition to white blood cell (WBC) and lymphocyte counts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>25 patients received etanercept and 25 conventional therapies (including methotrexate) for JIA. There was no difference between treatment and control groups in leptin or ghrelin levels and no evidence of a relationship between leptin and ghrelin in patients with JIA. In all children with JIA there was a correlation between leptin and body mass index (BMI). However, compared with children in the conventional treatment group, children in the etanercept group showed a positive correlation between total ghrelin and BMI and those with a low BMI showed a negative correlation between acyl ghrelin and BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No differences in leptin and ghrelin concentrations were found when patients with JIA and controls were compared or when patients who received etanercept were compared with those who received conventional treatment for JIA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060516688340","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T05:29:13Z","timestamp":1488864553000},"page":"525-532","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of etanercept on leptin and ghrelin secretion in children with juvenile idiopathic arthritis"],"prefix":"10.1177","volume":"45","author":[{"given":"Izabela","family":"Maciejewska-Paszek","sequence":"first","affiliation":[{"name":"Department of Health Promotion and Community Nursing, Faculty of Health Sciences, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Grochowska-Niedworok","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Faculty of Public Health, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Siwiec","sequence":"additional","affiliation":[{"name":"The John Paul II Pediatric Center, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gruenpeter","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The John Paul II Pediatric Center, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lechos\u0142aw","family":"Dul","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Public Health, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Irzyniec","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and Community Nursing, Faculty of Health Sciences, Medical University of Silesia, Katowice, Poland"},{"name":"Department of Nephrology\/ENDO MSWiA Hospital, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"bibr1-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60363-8"},{"key":"bibr2-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.840580"},{"key":"bibr3-0300060516688340","unstructured":"Polish Agency for Health Technology Assessment and Pricing and Department of Health Technology Assessment. [in Polish]. Available from: http:\/\/bipold.aotm.gov.pl\/assets\/files\/zlecenia_mz\/(2015)\/089\/RPT\/AOTMiT_OT_434_10_RZS_(2015)0727.pdf accessed 15 February 2017."},{"key":"bibr4-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.013"},{"key":"bibr5-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2006.00270.x"},{"key":"bibr6-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900637"},{"key":"bibr7-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1177\/147323000903700523"},{"key":"bibr8-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302012000900001"},{"key":"bibr9-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.12.018"},{"key":"bibr10-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.10.008"},{"key":"bibr11-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9150-0"},{"key":"bibr12-0300060516688340","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2015.0013"},{"key":"bibr13-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.03.006"},{"key":"bibr14-0300060516688340","first-page":"147","volume":"16","author":"Nikolopoulos D","year":"2010","journal-title":"Med Sci Monit"},{"key":"bibr15-0300060516688340","doi-asserted-by":"crossref","unstructured":"Nistala K, et\u00a0al. Juvenile idiopathic arthritis. In\n                      : Kelley's Textbook of Rheumatology, 8th ed\n                      . (GS Firestein et\u00a0al., eds), Philadelphia: Saunders Elsevier, 2009: vol. 2; pp. 1657\u20131675.","DOI":"10.1016\/B978-1-4160-3285-4.10097-X"},{"key":"bibr16-0300060516688340","unstructured":"Fink CW and the ILAR Task Force for Classification Criteria. A proposal for the development of classification criteria for the idiopathic arthritides of childhood.\n                      J Rheumatol\n                      1995; 22: 1566\u20131569."},{"key":"bibr17-0300060516688340","first-page":"1991","volume":"25","author":"Petty RE","year":"1998","journal-title":"Rheumatol"},{"key":"bibr18-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1358"},{"key":"bibr19-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1002\/art.24777"},{"key":"bibr20-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2012.633509"},{"key":"bibr21-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22112"},{"key":"bibr22-0300060516688340","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq308"},{"key":"bibr23-0300060516688340","doi-asserted-by":"crossref","unstructured":"Stewart P.M. Krone N.P The Adrenal Cortex. In:\n                      Williams Textbook of Endocrinology. 12th ed\n                      . (Melmed S, Polonsky KS, Reed Larsen P, Kronenberg HM, eds). 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