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The most common causes of interruption of blood supply include fat embolism and coagulation disorders. GCs can directly or indirectly lead to coagulation disorders, producing a hypercoagulable state, followed by poor blood flow, ischaemia, and eventually ONFH. This review summarizes the existing knowledge on coagulation disorders in the context of GC-induced ONFH, including hypofibrinolysis and thrombophilia, endothelial cell dysfunction and damage, endothelial cell apoptosis, lipid metabolism, platelet activation, and the effect of anticoagulant treatment.<\/jats:p>","DOI":"10.1177\/0300060517700299","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T08:31:08Z","timestamp":1493627468000},"page":"2141-2148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Role of coagulopathy in glucocorticoid-induced osteonecrosis of the femoral head"],"prefix":"10.1177","volume":"46","author":[{"given":"Qiankun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Lishui Central Hospital, Lishui, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"L 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