{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:30:54Z","timestamp":1790109054106,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the association between low plasma Platelet-derived growth factor-BB (PDGF-BB) levels and oestradiol in Postmenopausal osteoporosis (PMOP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study measured plasma PDGF-BB and oestradiol levels in outpatients who were admitted to our hospital. Participants were screened and then allocated to three groups: normal young women, postmenopausal control, and PMOP. Additionally, Sprague\u2013Dawley rats underwent either sham surgery or bilateral ovariectomy (OVX), and were divided into the following groups: sham, OVX, OVX\u2009+\u2009oestradiol, and OVX\u2009+\u2009PDGF-BB. Plasma oestradiol and PDGF-BB levels were measured using commercially available ELISA kits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 121 participants, including 69 normal young women, 28 patients with primary PMOP, and 24 age-matched postmenopausal women were enrolled. Plasma oestradiol and PDGF-BB levels were lower in postmenopausal women, especially in PMOP ( P\u2009&lt;\u20090.01). Pearson correlations analysis showed that PDGF-BB levels were positively correlated with oestradiol levels and inversely correlated with age ( P\u2009&lt;\u20090.01). The OVX rat model showed that oestradiol replacement increased plasma PDGF-BB levels, while PDGF-BB systematic treatment had no effect on plasma oestradiol levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma PDGF-BB levels are maintained by oestrogen in normal young women and play a major role in PMOP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517706630","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T06:47:55Z","timestamp":1497336475000},"page":"1332-1339","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Low plasma PDGF-BB levels are associated with estradiol in postmenopausal osteoporosis"],"prefix":"10.1177","volume":"45","author":[{"given":"Lanhua","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Oncology, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuying","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"bibr1-0300060517706630","first-page":"403","volume":"59","author":"Erlik Y","year":"1982","journal-title":"Obstet Gynecol"},{"key":"bibr2-0300060517706630","doi-asserted-by":"crossref","unstructured":"Management of osteoporosis in postmenopausal women: 2010 position statement of The North American Menopause Society.\n                      Menopause\n                      2010; 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