{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:43:24Z","timestamp":1790131404200,"version":"4.0.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated infusion-related reactions associated with cetuximab combination chemotherapy comprising an H1-receptor antagonist plus dexamethasone as anti-allergy premedications for patients with head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated 248 patients who received a cetuximab combination regimen between December 2012 and August 2015. All patients received 5\u2009mg intravenous dichlorpheniramine (H1-receptor antagonist), and dexamethasone (DEX) was adjusted from 6.6\u2009mg to 13.2\u2009mg according to the emetogenic risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 248 subjects, including 13 (5.2%) with infusion-related reactions (grade 1 in five [2.0%], grade 2 in seven [2.8%], and grade 4 in one [0.4%]). The incidence of these reactions in cetuximab combination regimens, each employing an H1-receptor antagonist, using a higher dose of dexamethasone (13.2\u2009mg) was not significantly lower compared with those using 6.6\u2009mg DEX (2.4% vs 8.3%, respectively; p\u2009=\u20090.43). Twelve patients experienced infusion-related reactions associated with the first cetuximab administration, and one reaction occurred after the third administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of infusion-related reactions was lower compared with those of previous studies. Dexamethasone combined with an H1-receptor antagonist was useful for preventing allergic responses. The incidence of infusion-related reactions was not lower with 13.2\u2009mg dexamethasone, and 6.6\u2009mg DEX prevented infusion-related reactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517713531","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T06:47:55Z","timestamp":1497336475000},"page":"1378-1385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Retrospective analysis of premedication, glucocorticosteroids, and H\n                    <sub>1<\/sub>\n                    -antihistamines for preventing infusion reactions associated with cetuximab treatment of patients with head and neck cancer"],"prefix":"10.1177","volume":"45","author":[{"given":"Kiwako","family":"Ikegawa","sequence":"first","affiliation":[{"name":"Department of Pharmacy, National Cancer Center Hospital East, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Cancer Center Hospital East, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanaga","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Cancer Center Hospital East, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Enokida","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Endo","sequence":"additional","affiliation":[{"name":"The Japanese Society of Hospital Pharmacists, Shibuya, Japan"},{"name":"Department of Drug Safety Management, Meiji Pharmaceutical University, Kiyose, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Cancer Center Hospital East, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Cancer Center Hospital East, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology, National Research and Development Agency, Kashiwa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"bibr1-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074943"},{"key":"bibr2-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7447"},{"key":"bibr3-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053422"},{"key":"bibr4-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033025"},{"key":"bibr5-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.182"},{"key":"bibr6-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3758"},{"key":"bibr7-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8397"},{"key":"bibr8-0300060517713531","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24945"},{"key":"bibr9-0300060517713531","first-page":"72","volume":"8","author":"George 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