{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:32:57Z","timestamp":1790947977609,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>As part of a consultant\u2013patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98\u2009mg\/L (range, 0.50\u201317.40; reference range, 5\u201315\u2009mg\/L). A low plasma level with vitamin C insufficiency (&lt;5\u2009mg\/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (&lt;1.5\u2009mg\/L) was found in 6 (3.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517714387","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:47:43Z","timestamp":1501548463000},"page":"168-174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["Plasma concentrations of ascorbic acid in a cross section of the German population"],"prefix":"10.1177","volume":"46","author":[{"given":"Alexander F.","family":"Hagel","sequence":"first","affiliation":[{"name":"Department of Medicine 1, University of Erlangen \u2013 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University of Erlangen \u2013 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Dauth","sequence":"additional","affiliation":[{"name":"Institute of Employment Research, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hagel","sequence":"additional","affiliation":[{"name":"Department of Medicine 6, Paracelsus Medical University, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vitali","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University of Erlangen \u2013 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Ganzleben","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University of Erlangen \u2013 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans W.","family":"Schultis","sequence":"additional","affiliation":[{"name":"Synlab, Weiden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Konturek","sequence":"additional","affiliation":[{"name":"Thuringia Clinics, Gastroenterology, Saalfeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Nutritional Medicine, Sachsenhausen University Hospital, Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University of Erlangen \u2013 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Raithel","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, University of Erlangen \u2013 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp156"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003910050072"},{"key":"e_1_3_3_5_2","first-page":"236","volume-title":"Ergebnisse der Nationalen Verzehrsstudie \u00fcber die Lebensmittel- und N\u00e4hrstoffaufnahme in der Bundesrepublik Deutschland. 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