{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:39:07Z","timestamp":1777729147013,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To identify potential genes that may be involved in lipid metabolism in rats after treatment with aqueous extract of\n                      <jats:italic toggle=\"yes\">Arctium lappa<\/jats:italic>\n                      L (burdock).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were randomly divided into six groups: (i) control (standard diet); (ii) model group (high-fat diet only); (iii) high-fat diet and low-dose aqueous burdock root extract (2\u2009g\/kg); (iv) high-fat diet and moderate-dose aqueous burdock root extract (4\u2009g\/kg); (v) high-fat diet and high-dose aqueous burdock root extract (8\u2009g\/kg); and (vi) a positive control group exposed to a high-fat diet and simvastatin (10\u2009mg\/kg). Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was performed to find the potential candidate genes involved in the modulation of blood lipids by treatment with aqueous burdock root extract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Burdock root extract reduced body weight and cholesterol levels in rats. KEGG analysis revealed 113 genes that were involved in metabolic pathways. Of these, 27 potential genes associated with blood lipid metabolism were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aqueous extract of burdock root reduced body weight and cholesterol in rats, possibly by modulating the differential expression of genes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517716341","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T09:06:49Z","timestamp":1501492009000},"page":"158-167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of aqueous extract of\n                    <i>Arctium lappa<\/i>\n                    L. roots on serum lipid metabolism"],"prefix":"10.1177","volume":"46","author":[{"given":"Bo","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wencheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Centre for Disease Control and Prevention, Qingdao, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Qingdao University Medical College, Qingdao, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanglang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Qingdao University Medical College, Qingdao, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200604000-00002"},{"key":"e_1_3_3_3_2","first-page":"780","article-title":"The obesity epidemic: challenges, health initiatives, and implications for gastroenterologists","volume":"6","author":"Hurt RT","year":"2010","unstructured":"Hurt RT, Kulisek C, Buchanan LA, et al. 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