{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:19:34Z","timestamp":1793110774195,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the epidemiology and changes in antibacterial susceptibility of children in Shenmu City, northern Shaanxi, and provide a basis for rational drug use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The distribution and drug resistance pattern of pathogenic bacteria isolated from children were retrospectively analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 573 strains of pathogens were cultivated. A total of 201 (35.07%) strains of Gram-positive cocci and 183 (31.93%) strains of Gram-negative cocci were detected. A total of 189 (32.98%) strains of fungi were detected. The resistance rate of Staphylococcus to penicillin was 100% and that to erythromycin was 90.69%. There were varying degrees of resistance to other drugs, but no single strain had vancomycin resistance. Gram-negative bacilli were generally resistant to ampicillin, but had low resistance to the combined preparation of enzyme inhibitors, quinolones, and aminoglycosides, and were highly sensitive to imipenem and meropenem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gram-negative bacilli are the main pathogens of bacterial infection in the paediatric ward. Strengthening clinical monitoring of bacterial distribution in paediatric clinical isolates and understanding changes in drug resistance are important for guiding the rational use of antibiotics. These measures could also prevent emergence and spreading of resistant strains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517716343","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T01:58:44Z","timestamp":1502243924000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of distribution and antibiotic resistance of pathogens isolated from the paediatric population in Shenmu Hospital from 2011\u20132015"],"prefix":"10.1177","volume":"46","author":[{"given":"Yang","family":"Hui-min","sequence":"first","affiliation":[{"name":"Pediatrics Department, Shenmu Hospital, Shenmu City, Yulin City, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yan-ping","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Chinese Medicine Hospital, Yulin City, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lin Liu","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Shenmu Hospital, Shenmu City, Yulin City, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal Haider","family":"Shamsi","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Shenmu Hospital, Shenmu City, Yulin City, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Bo","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Yulin City, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xu-chun","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Shenmu Hospital, Shenmu City, Yulin City, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/541340"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/2047-2994-2-31"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70318-9"},{"key":"e_1_3_3_5_2","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola CL","year":"2015","unstructured":"Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T 2015; 40: 277\u2013277.","journal-title":"P T"},{"key":"e_1_3_3_6_2","first-page":"31","article-title":"Combating the rise of antibiotic resistance in children","volume":"66","author":"Nicolini G","year":"2014","unstructured":"Nicolini G, Sperotto F, Esposito S. Combating the rise of antibiotic resistance in children. Minerva Pediatr 2014; 66: 31\u201339.","journal-title":"Minerva Pediatr"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307762"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814001393"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i939"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-3201"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01027-16"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/649706"},{"key":"e_1_3_3_13_2","first-page":"19","article-title":"Changes in the disease spectrum of hospitalized children in a city hospital of China","volume":"36","author":"Liu Y","year":"2016","unstructured":"Liu Y, Liu J, Shamsi BH, et al. Changes in the disease spectrum of hospitalized children in a city hospital of China. 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Pattern of adverse drug reactions to antibiotics commonly prescribed in department of medicine and pediatrics in a tertiary care teaching hospital Ghaziabad; 2015.","DOI":"10.7324\/JAPS.2015.50413"},{"key":"e_1_3_3_22_2","first-page":"837","article-title":"Antimicrobial resistance monitoring of gram-negative bacilli isolated from 15 teaching hospitals in 2014 in China","volume":"54","author":"Wang Q","year":"2015","unstructured":"Wang Q, Wang H, Yu Y, et al. Antimicrobial resistance monitoring of gram-negative bacilli isolated from 15 teaching hospitals in 2014 in China. Zhonghua nei ke za zhi 2015; 54: 837\u2013845. 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