{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:20Z","timestamp":1787018780388,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of ondansetron during cesarean section under spinal anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We sought randomized controlled trials (RCTs) on ondansetron during spinal anesthesia for cesarean section in The Cochrane Library, PubMed, MEDLINE, and Web of Science from their inception to September 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether, 21 RCTs were included in this study. Meta-analysis showed that the ondansetron group had a lower incidence of nausea\/vomiting and bradycardia than the placebo group during cesarean section under spinal anesthesia [relative risk (RR)\u2009=\u20090.43, 95% confidence interval (CI) (0.36, 0.51) and RR\u2009=\u20090.45, 95% CI (0.26, 0.80), respectively]. There were no significant differences in the incidences of pruritus, hypotension, or shivering during cesarean section under spinal anesthesia [RR\u2009=\u20090.92, 95% CI (0.83, 1.02); RR\u2009=\u20090.72 (0.50, 1.06), 95% CI (0.50, 1.06); and RR\u2009=\u20090.89, 95% CI (0.71, 1.11), respectively].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ondansetron effectively reduces the incidences of nausea\/vomiting and bradycardia under spinal anesthesia during cesarean section.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517716502","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T08:12:55Z","timestamp":1504167175000},"page":"654-662","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy of ondansetron for spinal anesthesia during 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