{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:34:21Z","timestamp":1785857661897,"version":"3.56.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    This study was a meta-analysis of randomized controlled trials (RCTs) of ranitidine as an adjunct for antipsychotic-induced weight gain in patients with schizophrenia. RCTs reporting weight gain or metabolic side effects in patients with schizophrenia were included. Case reports\/series, non-randomized or observational studies, reviews, and meta-analyses were excluded. The primary outcome measures were body mass index (BMI) (kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) and body weight (kg). Four RCTs with five study arms were identified and analyzed. Compared with the control group, adjunctive ranitidine was associated with marginally significant reductions in BMI and body weight. After removing an outlier study for BMI, the effect of ranitidine remained significant. Adjunctive ranitidine outperformed the placebo in the negative symptom score of the Positive and Negative Syndrome Scale. Although ranitidine was associated with less frequent drowsiness, other adverse events were similar between the two groups. Adjunctive ranitidine appears to be an effective and safe option for reducing antipsychotic-induced weight gain and improving negative symptoms in patients with schizophrenia. Larger RCTs are warranted to confirm these findings.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>PROSPERO: CRD42016039735<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517716783","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T12:21:39Z","timestamp":1500553299000},"page":"22-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials"],"prefix":"10.1177","volume":"46","author":[{"given":"Xiao-Jing","family":"Gu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Xinxiang Medical University Henan Mental Hospital, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Qingdao Mental Health Center, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Hu","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor S.","family":"Ungvari","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia\/Marian Centre, Perth, Australia"},{"name":"School of Psychiatry &amp; Clinical Neurosciences, University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee H.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Golenkov","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Medical Psychology, Chuvash State University, Cheboksary, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace K.I.","family":"Lok","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines H.I.","family":"Chow","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tao","family":"Xiang","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13060771"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.21"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000392"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.221"},{"key":"e_1_3_4_6_2","first-page":"331","article-title":"Metformin for treatment of clozapine-induced weight gain in adult patients with schizophrenia: a meta-analysis","volume":"27","author":"Liu Z","year":"2015","unstructured":"Liu Z, Zheng W, Gao S, et al. Metformin for treatment of clozapine-induced weight gain in adult patients with schizophrenia: a meta-analysis. Shanghai Arch Psychiatry 2015; 27: 331\u2013340.","journal-title":"Shanghai Arch Psychiatry"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12631"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000579"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12230"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu030"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.297"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/970730"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36391"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12205"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/639391"},{"key":"e_1_3_4_16_2","first-page":"560","article-title":"The effect of ranitidine on olanzapine-induced weight gain and metabolic dysfunction [In Chinese]","volume":"33","author":"Sun J","year":"2007","unstructured":"Sun J, Xi XD, Li Y, et al. The effect of ranitidine on olanzapine-induced weight gain and metabolic dysfunction [In Chinese]. Chinese Journal of Nervous and Mental Diseases 2007; 33: 560\u2013562.","journal-title":"Chinese Journal of Nervous and Mental Diseases"},{"key":"e_1_3_4_17_2","first-page":"433","article-title":"Effects of ranitidine on the glucose and lipid metabolism level and body mass of patients with olanzapine in treatment of schizophrenia [In Chinese]","volume":"16","author":"Liang MJ","year":"2016","unstructured":"Liang MJ. Effects of ranitidine on the glucose and lipid metabolism level and body mass of patients with olanzapine in treatment of schizophrenia [In Chinese]. 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[Randomized, open label study on the use of ranitidine at different doses for the management of weight gain associated with olanzapine administration]. Vertex 2003; 14: 85\u201396. 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