{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:19:53Z","timestamp":1778606393295,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      <jats:fn>\n                        <jats:label>*<\/jats:label>\n                        <jats:p>Chong Xie, Xiangfeng Chen, and Yulin Liu contributed equally to this work.<\/jats:p>\n                      <\/jats:fn>\n                      Genetic defects are identified in nearly 20% of infertile males. Determining the frequency and types of major genetic abnormalities in severe male infertility helps inform appropriate genetic counseling before assisted reproductive techniques.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cytogenetic results of 912 patients with non-obstructive azoospermia (NOA) and severe oligozoospermia (SOS) in Eastern China were reviewed in this multicenter study from January 2011 to December 2015. Controls were 215 normozoospermic men with offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among all patients, 22.6% (206\/912) had genetic abnormalities, including 27.3% (146\/534) of NOA patients and 15.9% (60\/378) of SOS patients. Chromosomal abnormalities (all autosomal) were detected in only 1.9% (4 \/215) of controls. In NOA patients, sex chromosomal abnormalities were identified in 25.8% (138\/534), of which 8% (43\/534) had a 47,XXY karyotype or its mosaic; higher than the SOS group prevalence (1.1%; 4\/378). The incidence of Y chromosome microdeletions was lower in the SOS group (13.2%; 50\/378) than in the NOA group (17.8%; 95\/534).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high prevalence of genetic abnormalities in our study indicates the importance of routine genetic testing in severe male infertility diagnosis. This may help determine the choice of assisted reproductive technique and allow specific pre-implantation genetic testing to minimize the risk of transmitting genetic defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060517718771","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T07:47:26Z","timestamp":1500623246000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia"],"prefix":"10.1177","volume":"46","author":[{"given":"Chong","family":"Xie","sequence":"first","affiliation":[{"name":"Assisted Reproductive Center, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Human Sperm Bank, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Ji Ai Genetic and IVF Institute, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengmu","family":"Wu","sequence":"additional","affiliation":[{"name":"Assisted Reproductive Center, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ping","sequence":"additional","affiliation":[{"name":"Assisted Reproductive Center, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)08341-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874255601103010042"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1635054100"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.04.041"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.1.82"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-9990-4"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9366-y"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.045"},{"key":"e_1_3_4_10_2","first-page":"1","article-title":"Genetic aspects of male infertility","volume":"17","author":"Asero P","year":"2010","unstructured":"Asero P, La Vignera S, Lanzafame F. Genetic aspects of male infertility. J Androl Sci 2010; 17: 1\u201316.","journal-title":"J Androl Sci"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(03)00150-0"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201263"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0879"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0775"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4103\/1008-682X.148719","article-title":"Clinical management of infertile men with nonobstructive azoospermia","volume":"17","author":"Esteves SC","year":"2015","unstructured":"Esteves SC. Clinical management of infertile men with nonobstructive azoospermia. Asina J Androl 2015; 17: 459\u2013470.","journal-title":"Asina J Androl"},{"key":"e_1_3_4_16_2","unstructured":"Mitelman F ISCN (eds). An international system for human cytogenetic nomenclature. Basel: Karger; 1995."},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60677-3"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-011-9633-6"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.04.041"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.004"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00200.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9420-9"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.03.034"},{"key":"e_1_3_4_24_2","first-page":"226","article-title":"Y chromosome microdeletions and alterations of spermatogenesis","volume":"22","author":"Foresta C","year":"2001","unstructured":"Foresta C, Moro E, Ferlin A. Y chromosome microdeletions and alterations of spermatogenesis. Endocr Rev 2001; 22: 226\u2013239.","journal-title":"Endocr Rev"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.12.3332"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327324"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.161238"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep180"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.019"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.6.080604.162350"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01556-9"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9160"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060517718771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060517718771","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060517718771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:54:13Z","timestamp":1777460053000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060517718771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,21]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1177\/0300060517718771"],"URL":"https:\/\/doi.org\/10.1177\/0300060517718771","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,21]]}}}